Results 211 to 220 of about 117,595 (294)

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction. [PDF]

Front Mol Biosci
Drongitis D, Verrillo L, de Bellis A, Miano MG.   +3 more
europepmc   +1 more source

Transcription Profiling of Potato Leaves in Response to Heat Stress at Single‐Cell Resolution

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2970-2987, May 2026.
ABSTRACT Potato (Solanum tuberosum L.) is a globally important food crop with considerable nutritional and economic value. Heat stress significantly inhibits potato plant growth and tuber development, constraining the sustainable development of the potato industry. Currently, studies on the cellular‐level mechanisms underlying heat adaptation in potato
Shiqi Wen, Ke Wang, Wenqian Liang, Rongrong Liu, Zihan Li, Xinlong Chen, Yan Li, Dianqiu Lv, Hongju Jian   +8 more
wiley   +1 more source

Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse. [PDF]

NAR Mol Med
Laurent J, Deramaudt TB, Cloix R, Robin V, Beley C, Garcia L, Bonay M.   +6 more
europepmc   +1 more source

The MdERF17–MdbHLH149 Module Mediates Ethylene‐Induced Starch Degradation Through the Transcriptional Repression of α‐Amylase MdAMY1 in Apple

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3141-3157, May 2026.
ABSTRACT The ripening of climacteric fruits is characterised by a sharp increase in ethylene production, coinciding with the conversion of starch into soluble sugars. However, the regulatory interplay between ethylene and starch degradation in apple remains largely unclear. Here, we report a negative correlation between starch accumulation and ethylene
Fan Xiao, Chu‐Kun Wang, Jiu‐Cheng Zhang, Xin‐Yue Jian, Ying Xiang, Wang‐Jiang Zhang, Jin‐Chao Meng, Wen‐Yan Wang, Da‐Gang Hu   +8 more
wiley   +1 more source

Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates. [PDF]

RSC Adv
Balachandran AA, Poudel BH, Rahimizadeh K, Chikkanna A, Veedu RN.   +4 more
europepmc   +1 more source

Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies. [PDF]

Mol Ther Nucleic Acids
Sokulska M, Nalewaj M, Czapik T, Rachwalak M, Szabat M.   +4 more
europepmc   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides. [PDF]

JACS Au
Yamaguchi T, Komine H, Sugiura T, Kumagai R, Yoshida T, Sasaki K, Nakayama T, Kamada H, Inoue T, Obika S.   +9 more
europepmc   +1 more source