Results 171 to 180 of about 414,656 (346)

Solid-phase oligonucleotide synthesis: a renaissance

, 1978
Michael J. Gait, R. C. Sheppard
openalex   +2 more sources

Oligonucleotide Conformations [PDF]

, 1972
Wilhelm Guschlbauer, I. Frič, Antonı́n Holý   +2 more
openalex   +1 more source

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations. [PDF]

Nucleic Acids Res
Christensen JK, Colletti N, Hooshfar S, Jiang RR, Kuo C, Lindmark B, Lumen A, Youssef AS, Albertolle M, Aluri KC, Chen L, Chen J, Chopda G, Chua XY, Morais P, Dubois B, Gibbons FF, Gudey SK, Gupta S, Hood S, Humphreys S, Husser C, Huth F, Jani D, Jian W, Kakuda T, Kurz J, Linnebjerg H, Liu J, Lohmann S, Niu T, Root K, Singla S, Tang C, Veluri R, Zhang GS, Zhang S, Jawa V.   +37 more
europepmc   +1 more source

Antibody-nucleic acid complexes. Immunospecific recognition of 7-methylguanine- and N6-methyladenine-containing 5'-terminal oligonucleotides of mRNA.

, 1979
Theodore W. Munns, Robert J. Oberst, Harold F. Sims, Megan K. Liszewski   +3 more
openalex   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Effective primer design for genotype and subtype detection of highly divergent viruses in large scale genome datasets. [PDF]

BMC Bioinformatics
Demiralay B, Can T.
europepmc   +1 more source

On the Mechanism of Oligonucleotide‐Primed DNA Synthesis [PDF]

, 1973
Wolfgang H. Oertel, Heinz Schaller
openalex   +1 more source

Tackling Allergic Airway Inflammation with Organic Sheet‐Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles

Advanced Science, EarlyView.
In this work, “inorganic‐free” nanosheets, named PNSE are developed using template‐based synthesis technology. The functionalized organic nanosheets exhibit low cytotoxicity, mild protein adsorption, and potent binding efficacy to epithelial sEVs.
Zhaoxu Tu, Junyan Lin, Zhixin Li, Yuefei Zhu, Changyi Xu, Zihan Qiu, Qiumin Wang, Yang Ye, Yihui Wen, Jian Li, Kam W. Leong, Weiping Wen   +11 more
wiley   +1 more source

Distribution of bromouracil in the pyrimidine oligonucleotides of drosophila DNA [PDF]

, 1975
Rose M. Rizki, T. M. Rizki
openalex   +1 more source