Results 191 to 200 of about 584,539 (379)

Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct intraparenchymal controlled-rate infusion [PDF]

, 1997
William C. Broaddus, Sujit S. Prabhu, G. T. Gillies, Jeffrey Neal, William S. Conrad, Zhijian Chen, Helen L. Fillmore, Harold F. Young   +7 more
openalex   +1 more source

Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

PCR methods and applications, 1995
Genome Research, Kenneth J. Livak, Susan J.A. Flood, Jeffrey Marmaro, William Giusti, Karin Deetz   +5 more
semanticscholar   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application [PDF]

, 2001
Cheng Li, Wing Hung Wong
openalex   +1 more source

Oligonucleotides as Radiopharmaceuticals

, 2006
Oligonucleotide radiopharmaceuticals is a slowly but steadily progressing field. With a panel of labeling and imaging techniques mastered by several groups, imaging of oligonucleotides is now relatively accessible and will be applied to more and more trials of oligonucleotide pharmacology.
openaire   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Editorial: New Advances in RNA Targeting

Frontiers in Pharmacology, 2020
Olga Ilinskaya, Derek J. Hausenloy, Derek J. Hausenloy, Derek J. Hausenloy, Derek J. Hausenloy, Derek J. Hausenloy, Hector A. Cabrera-Fuentes, Hector A. Cabrera-Fuentes, Marina Zenkova   +8 more
doaj   +1 more source

Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources. [PDF]

Foods
Du X, Chen Q, Zhuang J, Zhao M, Duan Y, Wang S, An R, Liang X.   +7 more
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Inhibition of Interleukin-4- and CD40-induced IgE Germline Gene Promoter Activity by 2′-Aminoethoxy-modified Triplex-forming Oligonucleotides [PDF]

, 2001
Adrian M. Stütz, Jutta Horejs‐Hoeck, François Natt, Bernard Cuenoud, Maximilian Woisetschläger   +4 more
openalex   +1 more source