Results 241 to 250 of about 414,656 (346)

Use of a Dihydroxyacetone Derivative as Protecting Reagent to Phosphorylate Oligonucleotides. [PDF]

Curr Protoc
Lartia R.
europepmc   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

A solid-phase enzymatic synthesis platform for the facile production of 2'-fluoroarabinonucleic acid (FANA) and chimeric XNA oligonucleotides using an evolved XNA polymerase. [PDF]

Nucleic Acids Res
Zhang B, Du Y, Zhang J, Ma X, Qin Y, Tao R, Luo M, Wu J, Sun L, Zhu G, Luo H, Wen J, Xiong C, Mei H, Chen T.   +14 more
europepmc   +1 more source

A polypeptide which reverses cap analogue inhibition of cell-free protein synthesis. Purification and binding to capped oligonucleotides.

, 1982
Gary M. Hellmann, Lee-Yun Chu, Robert E. Rhoads   +2 more
openalex   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

ASOG: AntiSense Oligonucleotide Generator. [PDF]

Comput Struct Biotechnol J
Kimi J, Korczak P, Vialet B, Roubin E, Barthélémy P, Campagne S, Malard F.   +6 more
europepmc   +1 more source

Designing chemically modified oligonucleotides for targeted gene silencing.

Chemistry and Biology, 2012
G. Deleavey, M. Damha
semanticscholar   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Enhanced Protein Precipitation with Ammonia Enables Rapid, Universal Extraction of Oligonucleotides for Bioanalysis. [PDF]

ACS Omega
Kamali A, Shelke JD, Sanford EJ, Hayashi MM, Chaisakhon N, Kolakowski RV, Puri S, Zhang G.   +7 more
europepmc   +1 more source

Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.

Nucleic Acid Therapeutics, 2014
R. Juliano, Xin Ming, Kyle Carver, B. Laing   +3 more
semanticscholar   +1 more source