Results 251 to 260 of about 414,656 (346)

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase. [PDF]

Org Lett
Chik GJ, El-Sagheer AH, Brown T.
europepmc   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source

Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications. [PDF]

Nano Lett
Mohora I, Patiño Guillén G, Neis K, Valero J, Keyser UF, Bošković F.   +5 more
europepmc   +1 more source

Ligation of oligonucleotides to nucleic acids or proteins via disulfide bonds

, 1988
Barbara C.F. Chu, Leslie E. Orgel
openalex   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice

Advanced Science, EarlyView.
The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu, Niannian Chen, Xiaowei Fan, Xueqing Xia, Yilong Yao, Wen Huang, Jin Sun, Lintao Huang, Lei Wang, Hong Yu, Jiayang Li, Yongzhong Xing   +11 more
wiley   +1 more source

Correction: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics. [PDF]

J Pharmacokinet Pharmacodyn
Derbalah A, Stader F, Liu C, Zyla A, Abdulla T, Wu Q, Jamei M, Gardner I, Sepp A.   +8 more
europepmc   +1 more source

Comparative study of colony hybridization with synthetic oligonucleotide probes and enzyme-linked immunosorbent assay for identification of enterotoxigenic Escherichia coli

, 1988
Halvor Sommerfelt, A.‐M. Svennerholm, Karl-H. Kalland, Bjørn Ivar Haukanes, Bjarne Bjorvatn   +4 more
openalex   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source