Results 31 to 40 of about 414,656 (346)
ChemistryOpen, 2020 DNA was used as supramolecular scaffold to order chromophores and control their optical properties. Ethynylpyrene as energy donor was attached to 2′‐desoxy‐2‐aminoadenosine that binds selectively to thymidines (T) in the template.
Sara Müller +2 more
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A microfluidic oligonucleotide synthesizer [PDF]
Nucleic Acids Research, 2010 De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods. The ability to mass produce synthetic genes holds great potential for biological research, but widespread availability of de novo DNA constructs is currently hampered by their high cost ...
Lee, Cheng-Chung +2 more
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Molecular Mechanisms of Antisense Oligonucleotides
Nucleic Acid Therapeutics, 2017 In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems.
S. Crooke
semanticscholar +2 more sources
Synthesis of Unmodified Oligonucleotides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/152987/1/cpnc0300 ...
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Проблемы особо опасных инфекций, 2020 Objective of the study is to analyze the genetic markers of tick-borne encephalitis virus, which can be used to specifically indicate the maximum number of virus strains and isolates.Materials and methods.
N. I. Khammadov
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Molecules, 2021 Selective regulation of gene expression by means of RNA interference has revolutionized molecular biology. This approach is not only used in fundamental studies on the roles of particular genes in the functioning of various organisms, but also possesses ...
Tatiana S. Golubeva +2 more
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Splice-switching antisense oligonucleotides as therapeutic drugs
Nucleic Acids Research, 2016 Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA–RNA base-pairing or protein–RNA binding ...
Mallory A. Havens, M. Hastings
semanticscholar +1 more source
Molecules, 2012 There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Wei Gong +2 more
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Oligomeric Nucleic Acids as Antivirals
Molecules, 2011 Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years.
Alessandra Mescalchin, Tobias Restle
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Factors Impacting Invader-Mediated Recognition of Double-Stranded DNA
Molecules, 2022 The development of chemically modified oligonucleotides enabling robust, sequence-unrestricted recognition of complementary chromosomal DNA regions has been an aspirational goal for scientists for many decades.
Caroline P. Shepard +3 more
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