Results 31 to 40 of about 446,863 (330)
Antisense oligonucleotides for neurodegeneration [PDF]
Science, 2020 Promising clinical results for Huntington's disease give hope for other ...
Leavitt, BR, Tabrizi, SJ
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Pharmaceuticals, 2019 In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, three of them (5%) are TIDES (or also, -tides), two oligonucleotides and one peptide. Herein, the three TIDES approved are analyzed in terms of medical target,
Danah Al Shaer +3 more
doaj +1 more source
The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids [PDF]
, 2017 open5noBACKGROUND: G-quadruplexes (G4s) are four-stranded nucleic acid structures that form in G-rich sequences. Nucleolin (NCL) is a cellular protein reported for its functions upon G4 recognition, such as induction of neurodegenerative diseases, tumor
Elena Tosoni +4 more
core +1 more source
Synthesis of Unmodified Oligonucleotides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/152987/1/cpnc0300 ...
openaire +5 more sources
Проблемы особо опасных инфекций, 2020 Objective of the study is to analyze the genetic markers of tick-borne encephalitis virus, which can be used to specifically indicate the maximum number of virus strains and isolates.Materials and methods.
N. I. Khammadov
doaj +1 more source
A cellulose-based bioassay for the colorimetric detection of pathogen DNA [PDF]
, 2014 Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen DNA.
Goyal, Madhu +3 more
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, 2010 Mutations in the human ether-a-go-go-related gene (hERG) cause long-QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a ...
Bhuiyan +39 more
core +1 more source
Improved Lower Bounds for Constant GC-Content DNA Codes
, 2008 The design of large libraries of oligonucleotides having constant GC-content and satisfying Hamming distance constraints between oligonucleotides and their Watson-Crick complements is important in reducing hybridization errors in DNA computing, DNA ...
Chee, Yeow Meng, Ling, San
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2019 FDA TIDES (Peptides and Oligonucleotides) Harvest
Pharmaceuticals, 2020 2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES) approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in 2019 in comparison with 2018 (48 vs.
Danah Al Shaer +3 more
doaj +1 more source
Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter [PDF]
, 2017 EGFR is an oncogene which codifies for a tyrosine kinase receptor that represents an important target for anticancer therapy. Indeed, several human cancers showed an upregulation of the activity of this protein.
Cristofari, Camilla +5 more
core +1 more source