Results 31 to 40 of about 37,573 (244)

Antioxidant and Immunomodulatory Properties of Chia Protein Hydrolysates in Primary Human Monocyte–Macrophage Plasticity

Foods, 2022
Chia (Salvia hispanica L.) seed has high potential in the development of functional food due to its protein content with a special amino acid profile.
Alvaro Villanueva-Lazo, Sergio Montserrat-de la Paz, Elena Grao-Cruces, Justo Pedroche, Rocio Toscano, Francisco Millan, Maria C. Millan-Linares   +6 more
doaj   +1 more source

Short peptide sequences: current knowledge and future prospects [PDF]

The Ukrainian Biochemical Journal, 2021
According to modern knowledge, the biological effect of many peptides is mediated by their short-chain fragments – oligopeptides – ranging from 2 to 20 amino acids and the activity of short peptides often significantly exceeds the activity of the peptide
C. M. Nasadyuk
doaj   +1 more source

Further characterization of glycine-containing microcystins from the McMurdo Dry Valleys of Antarctica [PDF]

, 2015
Microcystins are hepatotoxic cyclic peptides produced by several cyanobacterial genera worldwide. In 2008, our research group identified eight new glycine-containing microcystin congeners in two hydro-terrestrial mat samples from the McMurdo Dry Valleys ...
Cary, S. Craig, Hamilton, David P., Holland, Patrick T., Prinsep, Michèle R., Puddick, Jonathan, Wood, Susanna A.   +5 more
core   +3 more sources

De novo Design of G Protein-Coupled Receptor 40 Peptide Agonists for Type 2 Diabetes Mellitus Based on Artificial Intelligence and Site-Directed Mutagenesis

Frontiers in Bioengineering and Biotechnology, 2021
G protein-coupled receptor 40 (GPR40), one of the G protein-coupled receptors that are available to sense glucose metabolism, is an attractive target for the treatment of type 2 diabetes mellitus (T2DM).
Xu Chen, Xu Chen, Zhidong Chen, Zhidong Chen, Daiyun Xu, Yonghui Lyu, Yongxiao Li, Shengbin Li, Junqing Wang, Zhe Wang   +9 more
doaj   +1 more source

Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms

Marine Drugs, 2023
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-
Wei Wang, Liting Gu, Jiahao Wang, Xubin Hu, Bin Wei, Huawei Zhang, Hong Wang, Jianwei Chen   +7 more
doaj   +1 more source

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. [PDF]

, 2016
We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal ...
Chen, Xigui, Finkbeiner, Steven, Fujita, Kyota, Homma, Hidenori, Ikura, Teikichi, Imamura, Tomomi, Ito, Nobutoshi, Kaye, Julia, Mao, Ying, Motoki, Kazumi, Nakabayashi, Makoto, Okano, Hideyuki, Okazawa, Hitoshi, Tagawa, Kazuhiko, Tamura, Takuya, Taniguchi, Juliana Bosso, Tomii, Kentaro, Yamada, Kazunori   +17 more
core   +2 more sources

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

Microbiology Spectrum, 2022
The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum.
Cecilia P. Sanchez, Erin D. T. Manson, Sonia Moliner Cubel, Luis Mandel, Stefan K. Weidt, Michael P. Barrett, Michael Lanzer   +6 more
doaj   +1 more source

Homochiral oligopeptides by chiral amplification: Interpretation of experimental data with a copolymerization model

, 2012
We present a differential rate equation model of chiral polymerization based on a simple copolymerization scheme in which the enantiomers are added to, or removed from, the homochiral or heterochiral chains (reversible stepwise isodesmic growth or ...
Akaike, Avetisov, Blair, Blair, Blanco, Blocher, Brack, Celia Blanco, Cintas, David Hochberg, Ehler, Hill, Hitz, Hitz, Hitz, Huber, Huber, Idelson, Joyce, Kanazawa, Kanazawa, Kondepudi, Kricheldorf, Leman, Lundberg, Pascal, Wattis, Weissbuch, Zepik   +28 more
core   +1 more source

Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]

, 2017
Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley, Bret N. Peterson, Daniel A. Portnoy, Jeff F. Miller, Jonathan L. Portman, Samuel B. Dubensky   +5 more
core   +2 more sources

Preparation, structural characteristics and antioxidant activity of Cardamine violifolia oligopeptides

Shipin yu jixie
Objective: This study aimed to prepare oligopeptidess of Camelina violifolia and expand its application range. Methods: C. violifolia protein was hydrolyzed by alkaline protease, and then used ultrafiltration membrane for isolating and concentrating, and
WEN Xiaolong, XIANG Jiqian, ZHANG Liang, LI Yajie, LONG Lan   +4 more
doaj   +1 more source