Results 61 to 70 of about 37,573 (244)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Binding of Ions to Oligopeptides

Biophysical Journal, 1973
A model for the binding of ions to oligopeptides, in which nearest neighbor interactions are considered is developed. Equations for the titration curves are derived The apparent association constants are determined as a function of the degree of polymerization and of the interactions between nearest neighbors.
openaire   +2 more sources

The EROP-Moscow oligopeptide database [PDF]

Nucleic Acids Research, 2006
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from >1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical and biological properties of these oligopeptides--whether synthesized on ribosomes or by non ...
Alexander A. Zamyatnin, Alexander S. Borchikov, Michail G. Vladimirov, Olga L. Voronina   +3 more
openaire   +2 more sources

Protein hydrolysates in cell culture: Toward multi‐omics characterization

Biotechnology Progress, EarlyView.
While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe, Brandon M. Wrage, Angel Varela‐Rohena, Stanislav Sokolenko   +3 more
wiley   +1 more source

Milk oligopeptide inhibition of (α)-tocopherol fortified linoleic acid oxidation

International Journal of Food Properties, 2019
This study investigated the effect of milk oligopeptides and (α)-tocopherol on inhibition of linoleic acid oxidation using Fe2+-vitamin C induced linoleic acid oxidation model through analysis of malondialdehyde, peroxide value, and conjugated diene and ...
Haina Yuan, Jinyan Gong, Kun Tang, Jinge Huang, Gongnian Xiao, Jianmin Lv   +5 more
doaj   +1 more source

Natural Antibodies Produced in Vaccinated Patients and COVID-19 Convalescents Recognize and Hydrolyze Oligopeptides Corresponding to the S-Protein of SARS-CoV-2

Vaccines, 2023
The S-protein is the major antigen of the SARS-CoV-2 virus, against which protective antibodies are generated. The S-protein gene was used in adenoviral vectors and mRNA vaccines against COVID-19.
Anna M. Timofeeva, Sergey E. Sedykh, Tatyana A. Sedykh, Georgy A. Nevinsky   +3 more
doaj   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Efficacy and safety of μ1-opioid receptor agonist (Taphalgin®) for emergency analgesia in outpatient practice

Saudi Journal of Anaesthesia
Background: A new peptide analgesic, a highly selective μ1-opioid receptor agonist (Taphalgin®) has shown the high efficacy in treating acute postoperative and chronic oncological pain, it appears to be a promising option for the treatment of patients ...
Alexey G. Voloshin, Kseniya N. Avetisova, Natal’ya V. Smirnova   +2 more
doaj   +1 more source

Indices of peroxidation of lipids of biological membranes and endogenous intoxication in patients with psoriasis on the background of chronic viral hepatitis С

Vestnik Dermatologii i Venerologii, 2019
Aim. To study the features of lipid peroxidation of biological membranes and accumulation of toxic metabolites in the body of patients with psoriasis, depending on the presence of concomitant chronic viral hepatitis C.Materials and methods. In the survey,
M. Yu. Marzhokhova, Ashour Ahmad Mahmud Hussein, A. R. Marzhokhova   +2 more
doaj   +1 more source

Bond-specific fragmentation of oligopeptides via electronic stopping of swift heavy ions in molecular films

Scientific Reports, 2022
Highly bond-specific fragmentation of oligopeptides induced by swift heavy ion (SHI) irradiation was investigated by means of mass spectrometry. In pronounced contrast to measurements of samples irradiated with keV ions, oligopeptides which were exposed ...
P. Schneider, P. Keller, I. Schubert, M. Bender, C. Trautmann, M. Dürr   +5 more
doaj   +1 more source