Results 11 to 20 of about 390,913 (262)

P-Selectin Inhibition and the Structure–Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides [PDF]

Marine Drugs
The selectin family constitutes a well-known class of immune-regulatory molecules, among which P-selectin has emerged as a therapeutic target for inflammatory thrombotic diseases due to its capacity to mediate the adhesion between multiple immune cell ...
Sujuan Li, Lisha Lin, Lian Yang, Ying Pan, Na Gao, Ronghua Yin, Chunyu Zeng, Jinhua Zhao   +7 more
doaj   +2 more sources

Structural Characterization and Heparanase Inhibitory Activity of Fucosylated Glycosaminoglycan from Holothuria floridana

Marine Drugs, 2021
Unique fucosylated glycosaminoglycans (FG) have attracted increasing attention for various bioactivities. However, the precise structures of FGs usually vary in a species-specific manner.
Xiang Shi, Ruowei Guan, Lutan Zhou, Zhichuang Zuo, Xuelin Tao, Pin Wang, Yanrong Zhou, Ronghua Yin, Longyan Zhao, Na Gao, Jinhua Zhao   +10 more
doaj   +1 more source

Preparation and Structure Characterization of High-Value Laminaria digitata Oligosaccharides

Frontiers in Nutrition, 2022
Algae-derived marine oligosaccharides have been reported to be promising bioactive compounds because of their various properties with health benefits and potential significance in numerous applications in industrial biotechnology.
Kit-Leong Cheong, Kit-Leong Cheong, Jia-Kang Li, Jia-Kang Li, Saiyi Zhong   +4 more
doaj   +1 more source

Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications

Molecules, 2015
Heparin and heparan sulphate (H/HS) are important members of the glycosaminoglycan family of sugars that regulate a substantial number of biological processes. Such biological promiscuity is underpinned by hetereogeneity in their molecular structure. The
Marek Baráth, Steen U. Hansen, Charlotte E. Dalton, Gordon C. Jayson, Gavin J. Miller, John M. Gardiner   +5 more
doaj   +1 more source

Biochemical studies on sphingolipids of Artemia franciscana: novel neutral glycosphingolipids[S]

Journal of Lipid Research, 2011
Neutral glycosphingolipids containing one to six sugars in their oligosaccharide chains have been isolated from cysts of the brine shrimp Artemia franciscana.
Hisao Kojima, Takemasa Shimizu, Mutsumi Sugita, Saki Itonori, Norihisa Fujita, Masahiro Ito   +5 more
doaj   +1 more source

Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity

Frontiers in Oncology, 2019
Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes.
Jlenia Brunetti, Giulia Riolo, Lorenzo Depau, Elisabetta Mandarini, Andrea Bernini, Evgenia Karousou, Alberto Passi, Alessandro Pini, Luisa Bracci, Chiara Falciani   +9 more
doaj   +1 more source

Amadori Products - Substrates and Inhibitors for Intestinal Brush Border Glycosidases

Czech Journal of Food Sciences, 2009
The effect of oligosaccharide-derived Amadori products on intestinal disaccharidases was investigated to answer the question, whether these products, ingested in relevant amounts with the daily diet, are degraded by carbohydrate-digesting enzymes and in ...
A. Seidowski, D. Lunow, T. Henle
doaj   +1 more source

Oligosaccharide Synthesis in Microreactors [PDF]

Organic Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Carrel, F., Geyer, K., Codée, J., Seeberger, P.   +3 more
openaire   +4 more sources

Sugar Type Discrimination in O-glycosylation Based on Protein Primary Sequences

Journal of Biomechanical Science and Engineering, 2013
Glycosylation is one of the most important protein post-translational modifications. O-glycosylation plays important roles in biological functions. There are several variations of O-glycosylation, with each having a different function.
Kenji ETCHUYA, Yuri MUKAI
doaj   +1 more source

Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human

Human Vaccines & Immunotherapeutics, 2019
Shigella are gram-negative bacteria that cause severe diarrhea and dysentery, with a high level of antimicrobial resistance. Disease-induced protection against reinfection in Shigella-endemic areas provides convincing evidence on the feasibility of a ...
Louis-Antoine Barel, Laurence A. Mulard
doaj   +1 more source