Results 61 to 70 of about 166,101 (303)

Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations [PDF]

, 2019
A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed structure–function ...
Yu, Yang, Tyrikos-Ergas, Theodore, Zhu, Yuntao, Fittolani, Giulio, Bordoni, Vittorio, Singhal, Ankush, Fair, Richard J., Grafmüller, Andrea, Seeberger, Peter H., Delbianco, Martina   +9 more
core   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Sustainable Food Systems: The Case of Functional Compounds towards the Development of Clean Label Food Products

Foods, 2022
The addition of natural components with functional properties in novel food formulations confers one of the main challenges that the modern food industry is called to face.
Maria Alexandri, Vasiliki Kachrimanidou, Harris Papapostolou, Aikaterini Papadaki, Nikolaos Kopsahelis   +4 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Anticancer Properties of Aqueous Extracts from Leguminosae

Nutraceuticals, 2022
Inflammation and cancer are diseases caused by genetic and environmental factors as well as altered microbiota. Diet plays a role, with leguminous such as beans (Phaseolus vulgaris, Vicia faba), chickpeas (Cicer arietinum), lentils (Lens culinaris), peas
Luca Serventi, Xuanyi Cai, Ruitian Chen, Nadeesha Dilrukshi, Jingyi Su, Refi Priskila Novaleta Tuange, Elizabeth Eilidh Ham   +6 more
doaj   +1 more source

Synthesis of Heparin Oligosaccharides. [PDF]

ChemInform, 2003
An efficient preparation of rare 2-O-benzoyl-3-O-benzyl-1,6-anhydro-beta-l-idopyranose from commercially available diacetone alpha-d-glucose in five straightforward steps is described here. With this key building block in hand, the total syntheses of heparin oligosaccharides with three, five, seven, and nine sugar units are successfully carried out.
Jinq-Chyi, Lee, Xin-An, Lu, Suvarn S, Kulkarni, Yuh-Sheng, Wen, Shang-Cheng, Hung   +4 more
openaire   +2 more sources

Oligosaccharide profiles of Asian commercial honeys [PDF]

, 2012
As part of the development of a method to detect honey in imported materials, a database of the oligosaccharide composition of a range of Asian commercial honeys has been prepared.
Dumté, Mérine Emilie Jennifer, Manley-Harris, Merilyn   +1 more
core   +1 more source

Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]

, 2015
Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus, Chabrol, Eric, de Paz, José L, Fieschi, Franck, Imberty, Anne, Muñoz-García, Juan C., Nieto, Pedro M., Rojo, Javier, Thomas, Aline, Vives, Romain R.   +9 more
core   +7 more sources

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

Genetic and environmental factors shaping goat milk oligosaccharide composition

Journal of Dairy Science
: Oligosaccharides (OS) in milk have been suggested to influence the health and development of the newborn by promoting growth of beneficial gut bacteria, stimulating brain development, and enhancing immune functions.
R Gonzalez-Prendes, R.P.M.A. Crooijmans, B. Dibbits, K. Laport, S. Breunig, P. Keijzer, L. Pellis, H. Bovenhuis   +7 more
doaj   +1 more source