Results 31 to 40 of about 4,948 (176)

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Study of seminal fluid parameters and fertility of male sickle-cell disease patients and potential impact of hydroxyurea treatment

Journal of Applied Hematology, 2016
Context: Male sickle-cell disease (SCD) patients often have moderate to severe hypogonadism resulting in abnormal seminal fluid parameters. Hydroxyurea (HU) used in SCD patients has been found to further aggravate the testicular dysfunction.
Lulup K Sahoo, Bipin K Kullu, Siris Patel, Pragyan Rout, Nayan K Patel, Prasanta Purohit, Satyabrata Meher   +6 more
doaj   +1 more source

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Elevated CD4+, CD8+, and Pro-inflammatory Cytokine Levels and H19 Hypomethylation are Associated with Reduced Sperm Motility in Oligoasthenoteratozoospermia: A Case-control Study

Dubai Medical Journal
Introduction: Oligoasthenoteratozoospermia (OAT) is a frequent cause of male reproductive issues, but its etiology remains unclear. This study investigated the associations between immune markers, epigenetic alterations, and sperm parameters in men with
Rehab Sh. Al-Maliki
doaj   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Do Infections Cause Oligospermia and Could Empiric Antibiotics Antiprotozoal and Antifungal Treat Oligospermia?

Gynecology Obstetrics & Reproductive Medicine, 2014
OBJECTIVE: Previous studies have shown some factors that contribute to the idiopathic oligospermia which is not significantly enough to have a definite treatment for oligospermia.
Mohammed Nabil Dajanı
doaj  

Associated Factors with Male Infertility: A Case Control Study [PDF]

Journal of Clinical and Diagnostic Research, 2014
Objective: Sperm analysis is an important step to evaluate and diagnose male’s infertility. The present study aimed to determine associated factors with males’ infertility by using semen analysis.
Mohammad Reza Hafezi Ahmadi, Masood Yasemi, Hadi Peyman, Karim Hemati, Javaher Khajavikhan, Monireh Yaghoubi, Lida Bimanand   +6 more
doaj   +1 more source

Influence of Arginine on Oligospermia

Experimental Biology and Medicine, 1947
Summary1. Eighteen infertile men with oligospermia received 1.8-2.7 g of arginine and minimal amounts of lysine, pyridoxine, and tryptophane in tablet form for 8 months.2. The tendency for sperm concentration to increase was as great in the untreated group as in the treated groups.3. Although no pregnancies occurred in the treated groups, 2 pregnancies
openaire   +2 more sources

Machine Learning‐Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation

Andrology, EarlyView.
ABSTRACT Background The Klinefelter syndrome is a common genetic cause of male infertility, and testicular sperm extraction (TESE) enables sperm retrieval in a subset of affected patients. However, predicting TESE success remains challenging due to the heterogeneous clinical and endocrinological presentation of the Klinefelter syndrome.
Murat Gül, Ali Şahin, Cevahir Özer, Mesut Altan, Tansu Güdelci, Kadir Can Sahin, Mehmet Hamza Gültekin, Muhammed Arif İbis, Mesut Berkan Duran, Burak Sivaslıoğlu, Eray Hasırcı, Mert Kılıç, Ali Can Albaz, Gökhan Çeker, Gianmaria Salvio   +14 more
wiley   +1 more source