Results 101 to 110 of about 853 (171)

Pathogenic characterization of Phialophora submersa, a new black yeast isolated from freshwater sediments in Spain

Frontiers in Cellular and Infection Microbiology
Phialophora submersa is a recently described black yeast species (Chaetothyriales), isolated from freshwater sediments in Catalonia (Spain). It is closely related to P. americana and P.
Ana Fernández-Bravo, Laura Camuña-Pardo, Marta Sanchis, Marta Sanchis, Youssef Ahmiane, Javier Capilla, Josepa Gené   +6 more
doaj   +1 more source

Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022:a genomic and phenotypic study [PDF]

Background: Aspergillus fumigatus is the main cause of invasive aspergillosis and triazole antifungals are the primary treatment option. The effectiveness of triazole therapy is hampered by the emergence of resistance, mainly caused by mutations in the ...
Bosch, Thijs, Buil, Jochem B, Ergün, Mehmet, Li, Ruoyu, Melchers, Willem J G, Rhodes, Johanna, Song, Yinggai, Tehupeiory-Kooreman, Marlou, Verweij, Paul E., Zhang, Jianhua, Zoll, Jan   +10 more
core   +1 more source

Additional file 2 of Review of the novel antifungal drug olorofim (F901318)

Supplementary Material ...
Vanbiervliet, Yuri, Van Nieuwenhuyse, Tine, Aerts, Robina, Lagrou, Katrien, Spriet, Isabel, Maertens, Johan   +5 more
openaire   +1 more source

Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen [PDF]

peer ...
Chapdelaine, Hugo, Desjardins, Michaël, Dufresne, Philippe J., Fournier Gosselin, Marie-Pierre, Luong, Me-Linh, Poirier, Charles, Schils, Raphael   +6 more
core   +1 more source

95. Novel Antifungal Olorofim Use in Intractable CNS and Non-CNS Disseminated Coccidioidomycosis [PDF]

Open Forum Infect Dis
Abstract Background Disseminated coccidioidomycosis (DCM) requires long courses of antifungal treatment. Olorofim, a novel antifungal in development, selectively blocks pyrimidine biosynthesis by inhibiting fungal dihydroorotate dehydrogenase (DHODH), and we evaluated its impact on clinical and ...
Donovan, Fariba, Thompson, George R, Johnson, Royce H, Kuran, Rasha, Patterson, Thomas F, Hoenigl, Martin, Schaenman, Joanna M, Shoham, Shmuel, Holland, Steven M, Sikka, Monica K, Spec, Andrej, Bresnik, Mark, Galgiani, John N, Rex, John H   +13 more
europepmc   +2 more sources

P-1098. Clinical outcomes in four patients with refractory Coccidioidal meningitis treated with olorofim [PDF]

Open Forum Infect Dis
Abstract Background Coccidioidal meningitis (CM) remains a highly morbid condition. Olorofim is a novel agent that inhibits the fungal dihydroorotate dehydrogenase enzyme and has potent in vitro activity against Coccidioidomycosis.
Yousefzadeh, Michelle, Goodman-Meza, David, Allyn, Paul R   +2 more
europepmc   +2 more sources

Clinical Mycology Today: Emerging challenges and opportunities [PDF]

The Mycoses Study Group Education and Research Consortium is a collective of clinicians, researchers, and educators with the common goal to advance awareness, diagnosis, and management of invasive fungal diseases.
Little, Jessica, McCarthy, Todd, Pappas, Peter, Perfect, John, Rauseo, Adriana M, Schwartz, Ilan S, Spec, Andrej, Zuniga-Moya, Julio C   +7 more
core   +2 more sources

Overcoming Global Antifungal Challenges: Medical and Agricultural Aspects [PDF]

The prevalence of fungal infections and contamination has increased alarmingly over the past decade, posing a significant threat to human health and the food supply and negatively affecting welfare.
Galgóczi László Norbert
core   +1 more source

Development of a novel patient-reported outcome measure for disseminated coccidioidomycosis (valley fever). [PDF]

BACKGROUND: Coccidioidomycosis (Valley Fever) is a dimorphic fungal infection endemic to the southwest United States, Mexico, Central and South America, which can lead to chronic debilitating illness and death.
Blatt, Elliott, Bresnik, Mark, Clegg, Jennifer, Harvey, Emma, Hughes, Sophie, Purdie, Rob, Symonds, Tara, Thompson, George, Umanzor-Figueroa, Cindy   +8 more
core   +1 more source

Update on therapeutic approaches for invasive fungal infections in adults

Therapeutic Advances in Infectious Disease
Invasive fungal infections are increasingly encountered with the expansion of iatrogenic immunosuppression, including not only solid organ and hematopoietic stem cell transplant recipients but also patients with malignancies or autoimmune diseases ...
Catherine-Audrey Boutin, Me-Linh Luong
doaj   +1 more source