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The technological landscape and applications of single-cell multi-omics
Nature Reviews Molecular Cell Biology, 2023 Single-cell multi-omics technologies and methods characterize cell states and activities by simultaneously integrating various single-modality omics methods that profile the transcriptome, genome, epigenome, epitranscriptome, proteome, metabolome and ...
Zhiliang Bai, Rahul Satija, Rong Fan
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Methods and applications for single-cell and spatial multi-omics
Nature Reviews Genetics, 2023 The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease.
Bernard Thienpont, Thierry Voet
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Multivariable association discovery in population-scale meta-omics studies
bioRxiv, 2021 It is challenging to associate features such as human health outcomes, diet, environmental conditions, or other metadata to microbial community measurements, due in part to their quantitative properties. Microbiome multi-omics are typically noisy, sparse
Himel Mallick +19 more
semanticscholar +1 more source
Squidpy: a scalable framework for spatial omics analysis
Nature Methods, 2022 Spatial omics data are advancing the study of tissue organization and cellular communication at an unprecedented scale. Flexible tools are required to store, integrate and visualize the large diversity of spatial omics data.
G. Palla +12 more
semanticscholar +1 more source
Combined sequence and copy number analysis improves diagnosis of limb girdle and other myopathies
Annals of Clinical and Translational Neurology, 2023 Objective Clinical and genetic heterogeneities make diagnosis of limb‐girdle muscular dystrophy (LGMD) and other overlapping disorders of muscle weakness complicated and expensive.
Babi R. R. Nallamilli +8 more
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A SNP variation in an expansin (EgExp4) gene affects height in oil palm [PDF]
PeerJ, 2022 Oil palm (Elaeis guineensis Jacq.), an Aracaceae family plant, is utilized for both consumable and non-consumable products, including cooking oil, cosmetics and biodiesel production.
Suthasinee Somyong +8 more
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Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
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Multi-omics single-cell data integration and regulatory inference with graph-linked embedding
Nature Biotechnology, 2022 Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets include only one modality.
Zhi-Jie Cao, Ge Gao
semanticscholar +1 more source
Clinical proteomics for precision medicine: the bladder cancer case [PDF]
, 2017 Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria +4 more
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Systems biology in inflammatory bowel diseases [PDF]
, 2014 Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
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