Results 91 to 100 of about 407,505 (399)

Advancements in Multiple Myeloma Research: High-Throughput Sequencing Technologies, Omics, and the Role of Artificial Intelligence

Biology
Multiple myeloma is a complex and challenging type of blood cancer that affects plasma cells in the bone marrow. In recent years, the development of advanced research techniques, such as omics approaches—which involve studying large sets of biological ...
Alejandra Gutiérrez-González, Irene Del Hierro, Ariel Ernesto Cariaga-Martínez   +2 more
doaj   +1 more source

Tunable fractionation of nucleic acids

BioTechniques, 2009
We developed a method for selective purification of DNA using the cationic detergent, cetyltrimethylammonium bromide (CTAB), accompanied with urea and controlled high-salt (NaCl) concentration.
Md. Salimullah, Sachiko Kato, Mitsuyoshi Murata, Chika Kawazu, Charles Plessy, Piero Carninci   +5 more
doaj   +1 more source

Deep learning-based approaches for multi-omics data integration and analysis

BioData Mining
The rapid growth of deep learning, as well as the vast and ever-growing amount of available data, have provided ample opportunity for advances in fusion and analysis of complex and heterogeneous data types. Different data modalities provide complementary
Jenna l. Ballard, Zexuan Wang, Wenrui Li, Li Shen, Qi Long   +4 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas, Jhamb, Deepali, Rajpal, Deepak K, Shu, Le, Yang, Xia, Zhao, Yuqi   +5 more
core   +3 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Genome sequencing of three bacteria associated to black band disease from a Colombian reef-building coral

Genomics Data, 2017
We announce the draft genome sequence of three Gram-negative bacteria isolated from coral tissues affected with the black band disease (BBD), identified with the NCBI's Assembly Database accession numbers: MBQF, MAYB and MBQE.
Juan Henao, Hermes Pérez, Deisy Abril, Katterine Ospina, Adriana Piza, Kelly Botero, Cristhian Rincón, Jhon Donato, Andrea Hurtado, Erika García, Vanessa Otero, Alexander Del Risco, Brenda Guerra, Yina Cifuentes, Alvaro Ordoñez, Daniel Rojas, Karen Suarez, Daniel Osorio, Andrés Pinzón   +18 more
doaj   +1 more source

The Personal Genome Project-UK, an open access resource of human multi-omics data [PDF]

, 2019
Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicated by the fact that the raw sequencing output
Beck, Stephan, Berner, Alison, Chervova, Olga, Conde, Lucia, Guerra-Assunção, José Afonso, Hamoudi, Rifat, Herrero, Javier, Jesus, Tiago F., Larose Cadieux, Elizabeth, Moghul, Ismail, Tian, Yuan, Voloshin, Vitaly, Webster, Amy P.   +12 more
core   +2 more sources

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

The Innovation, 2021
Tianzhi Wu, Erqiang Hu, Shuangbing Xu, Meijun Chen, Pingfan Guo, Zehan Dai, Tingze Feng, Lang Zhou, Wenli Tang, Li Zhan, Xiaocong Fu, Shanshan Liu, Xiaochen Bo, Guangchuang Yu   +13 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source