Results 11 to 20 of about 77,382 (200)

Omics and Multi-Omics in IBD: No Integration, No Breakthroughs

International Journal of Molecular Sciences, 2023
The recent advent of sophisticated technologies like sequencing and mass spectroscopy platforms combined with artificial intelligence-powered analytic tools has initiated a new era of “big data” research in various complex diseases of still-undetermined cause and mechanisms.
Claudio Fiocchi
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Network-based integration of multi-omics data for clinical outcome prediction in neuroblastoma

Scientific Reports, 2022
Multi-omics data are increasingly being gathered for investigations of complex diseases such as cancer. However, high dimensionality, small sample size, and heterogeneity of different omics types pose huge challenges to integrated analysis. In this paper,
Conghao Wang, Wu Lue, Rama Kaalia, Parvin Kumar, Jagath C. Rajapakse   +4 more
doaj   +2 more sources

Integration of Omics Data for Cancer Research

, 2009
The development of high-throughput techniques for analyzing cell components has provided vast amounts of data in recent years. This development of gene-sequencing methods was followed by advances in techniques for analyzing and managing data from transcriptomes, proteomes, and other omics data.
Martín, Luis, Anguita Sanchez, Alberto, Maojo García, Víctor Manuel, Crespo del Arco, Jose   +3 more
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A guide to multi-omics data collection and integration for translational medicine

Computational and Structural Biotechnology Journal, 2023
The emerging high-throughput technologies have led to the shift in the design of translational medicine projects towards collecting multi-omics patient samples and, consequently, their integrated analysis.
Efi Athieniti, George M. Spyrou
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Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values [PDF]

, 2022
Abnormal blood pressure is strongly associated with risk of high-prevalence diseases, making the study of blood pressure a major public health challenge. Although biological mechanisms underlying hypertension at the single omic level have been discovered,
Ollikainen Miina, Kähönen Mika, Mishra Pashupati P, Lehtimaki Terho, Drouard Gabin, Mykkänen Juha, Kaprio Jaakko, Wang Xiaoling L, Raitakari Olli   +8 more
core   +3 more sources

Effective integration of multi-omics with prior knowledge to identify biomarkers via explainable graph neural networks

npj Systems Biology and Applications
The rapid growth of multi-omics datasets and the wealth of biological knowledge necessitates the development of effective methods for their integration.
Rohit K. Tripathy, Zachary Frohock, Hong Wang, Gregory A. Cary, Stephen Keegan, Gregory W. Carter, Yi Li   +6 more
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Integrating omics databases for enhanced crop breeding

Journal of Integrative Bioinformatics, 2023
Crop plant breeding involves selecting and developing new plant varieties with desirable traits such as increased yield, improved disease resistance, and enhanced nutritional value.
Chao Haoyu, Zhang Shilong, Hu Yueming, Ni Qingyang, Xin Saige, Zhao Liang, Ivanisenko Vladimir A., Orlov Yuriy L., Chen Ming   +8 more
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Integrative omics for health and disease [PDF]

Nature Reviews Genetics, 2018
Advances in omics technologies - such as genomics, transcriptomics, proteomics and metabolomics - have begun to enable personalized medicine at an extraordinarily detailed molecular level. Individually, these technologies have contributed medical advances that have begun to enter clinical practice.
Konrad J, Karczewski, Michael P, Snyder
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Editorial: Multi-omic data integration [PDF]

Frontiers in Cell and Developmental Biology, 2015
As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter. The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions ...
Christine eNardini, Christine eNardini, Jennifer eDent, Paolo eTieri   +3 more
openaire   +5 more sources

Multi-modal intermediate integrative methods in neuropsychiatric disorders: A review

Computational and Structural Biotechnology Journal, 2022
The etiology of neuropsychiatric disorders involves complex biological processes at different omics layers, such as genomics, transcriptomics, epigenetics, proteomics, and metabolomics.
Yanlin Wang, Shi Tang, Ruimin Ma, Ibrahim Zamit, Yanjie Wei, Yi Pan   +5 more
doaj   +1 more source