Results 81 to 90 of about 77,382 (200)

Elucidating the Role of Chromatin State and Transcription Factors on the Regulation of the Yeast Metabolic Cycle: A Multi-Omic Integrative Approach

Frontiers in Genetics, 2018
The Yeast Metabolic Cycle (YMC) is a model system in which levels of around 60% of the yeast transcripts cycle over time. The spatial and temporal resolution provided by the YMC has revealed that changes in the yeast metabolic landscape and chromatin ...
Víctor Sánchez-Gaya, Salvador Casaní-Galdón, Manuel Ugidos, Zheng Kuang, Jane Mellor, Ana Conesa, Ana Conesa, Ana Conesa, Sonia Tarazona, Sonia Tarazona   +9 more
doaj   +1 more source

Recent advances in omics and the integration of multi-omics in osteoarthritis research

Arthritis Research & Therapy
Osteoarthritis (OA) is a complex disorder driven by the combination of environmental and genetic factors. Given its high global prevalence and heterogeneity, developing effective and personalized treatment methods is crucial. This requires identifying new disease mechanisms, drug targets, and biomarkers.
Ye Liu, Vladimir Molchanov, David Brass, Tao Yang   +3 more
openaire   +3 more sources

Vertical and horizontal integration of multi-omics data with miodin

, 2019
Background: Studies on multiple modalities of omics data such as transcriptomics, genomics and proteomics are growing in popularity, since they allow us to investigate complex mechanisms across molecular layers.
Ulfenborg, Benjamin
core   +1 more source

Multi-omics decodes host-specific and environmental microbiome interactions in sepsis

Frontiers in Microbiology
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and its pathogenesis involves complex interactions between the host and the microbiome.
Jiamin Lu, Jiamin Lu, Wen Zhang, Wen Zhang, Yuzhou He, Mei Jiang, Zhankui Liu, Jirong Zhang, Jirong Zhang, Lanzhi Zheng, Bingzhi Zhou, Jielian Luo, Jielian Luo, Chenming He, Chenming He, Yunan Shan, Runze Zhang, Runze Zhang, KaiLiang Fan, Bangjiang Fang, Bangjiang Fang, Chuanqi Wan, Chuanqi Wan   +22 more
doaj   +1 more source

Ovarian Cancer: Multi-Omics Data Integration

This study focuses on the systematization and integration of ovarian cancer multi-omics data, revealing patterns in the application of different omics-based approaches and assessing factors that affect the identification of potential biomarkers.
Olga Kiseleva, Elizaveta Sarygina, Anna Kliuchnikova, Arina Gordeeva, Svetlana Tarbeeva, Aziz Abdurakhimov, Tatiana Materova, Elena Ponomarenko, Anna Kozlova, Ekaterina Ilgisonis   +9 more
core   +1 more source

scCross: a deep generative model for unifying single-cell multi-omics with seamless integration, cross-modal generation, and in silico exploration

Genome Biology
Single-cell multi-omics data reveal complex cellular states, providing significant insights into cellular dynamics and disease. Yet, integration of multi-omics data presents challenges.
Xiuhui Yang, Koren K. Mann, Hao Wu, Jun Ding   +3 more
doaj   +1 more source

MUUMI: an R package for statistical and network-based meta-analysis for multi-omics data integration

BMC Bioinformatics
Background Disentangling physiopathological mechanisms of biological systems through high-level integration of omics data has become a standard procedure in life sciences.
Simo Inkala, Michele Fratello, Giusy del Giudice, Giorgia Migliaccio, Angela Serra, Dario Greco, Antonio Federico   +6 more
doaj   +1 more source

Application of Multi-Omics Techniques in Aquatic Ecotoxicology: A Review

Toxics
Traditional ecotoxicology primarily investigates pollutant toxicity through physiological, biochemical, and single-molecular indicators. However, the limited data obtained through this approach constrain its application in the mechanistic analysis of ...
Boyang Li, Yizhang Zhang, Jinzhe Du, Chen Liu, Guorui Zhou, Mingrui Li, Zhenguang Yan   +6 more
doaj   +1 more source

Machine learning-driven multi-omics for optimizing biotherapeutic production

Polson, Shawn W.Biotherapeutics, particularly monoclonal antibodies (mAbs) and recombinant adeno-associated viruses (rAAVs), have transformed the treatment landscape for various diseases.
Gurazada, Sai Guna Ranjan
core   +1 more source

Revolutionizing Personalized Medicine: Synergy with Multi-Omics Data Generation, Main Hurdles, and Future Perspectives

Biomedicines
The field of personalized medicine is undergoing a transformative shift through the integration of multi-omics data, which mainly encompasses genomics, transcriptomics, proteomics, and metabolomics.
Getnet Molla, Molalegne Bitew
doaj   +1 more source