Results 71 to 80 of about 77,382 (200)
CEN‐tools: an integrative platform to identify the contexts of essential genes
Molecular Systems Biology, 2020 An emerging theme from large‐scale genetic screens that identify genes essential for cell fitness is that essentiality of a given gene is highly context‐specific.
Sumana Sharma +4 more
doaj +1 more source
Omics and Lung Function: A Need for Integration [PDF]
American Journal of Respiratory and Critical Care Medicine, 2022 John W. Holloway, Dawn L. DeMeo
openaire +3 more sources
By using omics, we can now examine all components of biological systems simultaneously. Deep learning-based drug prediction methods have shown promise by integrating cancer-related multi-omics data.
Jung-Hsien Chiang +3 more
core +1 more source
Integration of multi-omics datasets enables molecular classification of COPD
, 2018 Chronic obstructive pulmonary disease (COPD) is an umbrella diagnosis caused by a multitude of underlying mechanisms, and molecular sub-phenotyping is needed to develop molecular diagnostic/prognostic tools and efficacious treatments.The objective of ...
Åsa M. Wheelock +3 more
core +1 more source
Integration of online omics-data resources for cancer research
, 2020 The manifestations of cancerous phenotypes necessitate alterations at different levelsof information-flow from genome to proteome. The molecular alterations at differentinformation processing levels serve as the basis for the cancer phenotype ...
Chakraborty, Sajib +3 more
core +1 more source
Omics Integration for Mitochondria Systems Biology
Antioxidants & Redox Signaling, 2020 Significance: Elucidation of the central importance of mitophagy in homeostasis of cells and organisms emphasizes that mitochondrial functions extend far beyond short-term needs for energy production. In mitochondria systems biology, the mitochondrial genome, proteome, and metabolome operate as a functional network in coordination of cell activities ...
Xin, Hu, Young-Mi, Go, Dean P, Jones
openaire +3 more sources
Integrative Omics for Interactomes
, 2018 Single-layer omics provide limited insight, whereas integrated multi-omics layers allow understanding of their combined influence on the complex biological process. The integrative omics approach has been initially applied to cancer research and later used in understanding host-pathogen interactions and pluripotency regulatory networks in stem cells ...
Debangana Chakravorty +2 more
openaire +1 more source
Statistical integration of diverse omics data
, 2020 This thesis is concerned with statistical methodology for jointly analyzing multiple types of omics data. These datasets provide information on several biological levels, and an integrated analysis can lead to a better understanding of whole biological ...
Bouhaddani, S. el
core
DataSheet_1_Data Integration in Poplar: ‘Omics Layers and Integration Strategies.pdf
, 2019 Populus trichocarpa is an important biofuel feedstock that has been the target of extensive research and is emerging as a model organism for plants, especially woody perennials. This research has generated several large ‘omics datasets. However, only few
Deborah Weighill (5206256) +3 more
core +1 more source
Development of K-CORE: a web-based platform for integrated clinico-genomic analysis
Life Science AllianceK-CORE enables no-code integration and visualization of user-uploaded clinical and multi-omics cancer data for accessible precision oncology research. One of the key challenges in cancer treatment and precision oncology is the use of multi-omics data and
Juyeon Hwang +14 more
doaj +1 more source