Results 61 to 70 of about 77,382 (200)

MIntO: A Modular and Scalable Pipeline For Microbiome Metagenomic and Metatranscriptomic Data Integration

Frontiers in Bioinformatics, 2022
Omics technologies have revolutionized microbiome research allowing the characterization of complex microbial communities in different biomes without requiring their cultivation.
Carmen Saenz, Eleonora Nigro, Vithiagaran Gunalan, Manimozhiyan Arumugam   +3 more
doaj   +1 more source

An Integrated Multi-Disciplinary Perspectivefor Addressing Challenges of the Human Gut Microbiome

Metabolites, 2020
Our understanding of the human gut microbiome has grown exponentially. Advances in genome sequencing technologies and metagenomics analysis have enabled researchers to study microbial communities and their potential function within the context of a range
Rohan M. Shah, Elizabeth J. McKenzie, Magda T. Rosin, Snehal R. Jadhav, Shakuntla V. Gondalia, Douglas Rosendale, David J. Beale   +6 more
doaj   +1 more source

Integrating omics datasets with the OmicsPLS package [PDF]

BMC Bioinformatics, 2018
With the exponential growth in available biomedical data, there is a need for data integration methods that can extract information about relationships between the data sets. However, these data sets might have very different characteristics. For interpretable results, data-specific variation needs to be quantified.
Bouhaddani, S. el, Uh, H.W., Jongbloed, G., Hayward, C., Klaric, L., Kielbasa, S.M., Houwing-Duistermaat, J.   +6 more
openaire   +10 more sources

Integrative Multi-omics Analyses of Barley Rootzones under Salinity Stress Reveal Two Distinctive Salt Tolerance Mechanisms

Plant Communications, 2020
The mechanisms underlying rootzone-localized responses to salinity during early stages of barley development remain elusive. In this study, we performed the analyses of multi-root-omes (transcriptomes, metabolomes, and lipidomes) of a domesticated barley
William Wing Ho Ho, Camilla B. Hill, Monika S. Doblin, Megan C. Shelden, Allison van de Meene, Thusitha Rupasinghe, Antony Bacic, Ute Roessner   +7 more
doaj   +1 more source

Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy

Discover Oncology
Cancer nanomedicine has emerged as a transformative approach in oncology, providing targeted therapeutic strategies with enhanced efficacy and reduced systemic toxicity.
Lihui Yan, Boshi Duan, Tianyou Wang, Tianzuo Wang, Huanyu Chi, Hongji Gao   +5 more
doaj   +1 more source

An overview of single-cell omics, spatial omics, and omics integration in axon regeneration

Toward a systems approach for studying axon regeneration, the extractive omics must be integrated with single cell and spatial omics. Although a comprehensive analytical framework exists for single-cell transcriptomics, single-cell proteomics, lipidomics,
Coronado, Michael, Singal, Avani, Bhattacharya, Sanjoy K., Neag, Emily, Bhattacharya, Nivedita, Almobayed, Amr, Gandikota, Nikhil, Akurati, Sneha, Kishor, Krishna S.   +8 more
core   +1 more source

DBCL-DFNet: Dual-Branch Contrastive Learning for Multi-Omics Dynamic Fusion

Entropy
Multimodal omics data portray biological processes across molecular layers, yet their heterogeneity and high dimensionality hinder a unified representation. Existing integrative approaches either focus on local feature interactions or adopt static fusion,
Yun Dang, Xiaoran Yan, Li Zhou, Dongxi Li   +3 more
doaj   +1 more source

Evaluation of O2PLS in Omics data integration [PDF]

BMC Bioinformatics, 2016
Rapid computational and technological developments made large amounts of omics data available in different biological levels. It is becoming clear that simultaneous data analysis methods are needed for better interpretation and understanding of the underlying systems biology.
Said el Bouhaddani, Jeanine J. Houwing-Duistermaat, Perttu Salo, Markus Perola, Geurt Jongbloed, Hae-Won Uh   +5 more
openaire   +7 more sources

Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine

Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy ...
Delrue, Charlotte, Marijn M. Speeckaert, Charlotte Delrue, Speeckaert, Marijn   +3 more
core   +1 more source

Network-based multi-omics integrative analysis methods in drug discovery: a systematic review

BioData Mining
The integration of multi-omics data from diverse high-throughput technologies has revolutionized drug discovery. While various network-based methods have been developed to integrate multi-omics data, systematic evaluation and comparison of these methods ...
Wei Jiang, Weicai Ye, Xiaoming Tan, Yun-Juan Bao   +3 more
doaj   +1 more source