Results 101 to 110 of about 1,399,412 (310)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Use of Machine Learning for Partial Discharge Discrimination [PDF]

, 2009
Partial discharge (PD) measurements are an important tool for assessing the condition of power equipment. Different sources of PD have different effects on the insulation performance of power apparatus.
Hao, L, Swingler, S G, Lewin, P L
core  

Novel, High-Precision, On-Machine Approach for Measuring Cup Grinding Wheel Wear Using a Moveable Laser Displacement Sensor

Journal of Manufacturing and Materials Processing
This study developed a movable, high-precision laser measurement system for assessing wear on cup grinding wheels. The proposed setup employs a Keyence CL-P070 laser sensor with a resolution of 0.25 μm and has a simple installation process that supports ...
Chung-Ying Wang, Chien-Yao Huang, Yen-Han Chiang   +2 more
doaj   +1 more source

Measurements of collective machine intelligence

CoRR, 2013
Independent from the still ongoing research in measuring individual intelligence, we anticipate and provide a framework for measuring collective intelligence. Collective intelligence refers to the idea that several individuals can collaborate in order to achieve high levels of intelligence.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Neural machine translation of literary texts from English to Slovene [PDF]

, 2019
Neural Machine Translation has shown promising performance in literary texts. Since literary machine translation has not yet been researched for the English-toSlovene translation direction, this paper aims to fulfill this gap by presenting a comparison ...
Kuzman, Taja, Arčan, Mihael, Vintar, Špela   +2 more
core   +1 more source

Performance of a five-axis machine tool as a coordinate measuring machine (CMM)

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
The use of machine tools for on-machine coordinate measurement on the workpiece is becoming commonplace. However, numerous errors can adversely affect the measurement accuracy. For instance, the inter-axis parameters are major contributors to the overall
Md Mizanur RAHMAN, Rene MAYER
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source