Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Nine-Probe Third-Order Matrix System for Precise Flatness Error Detection
MachinesLarge-scale, high-density flatness measurement is critical for manufacturing reference surfaces in ultra-precision machine tools. Traditional methods exhibit degradation in both accuracy and efficiency as measurement points and area size increase.
Hua Liu +5 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Compact snapshot dual-mode interferometric system for on-machine measurement. [PDF]
Opt Lasers Eng, 2020 Wang D +7 more
europepmc +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Investigation of the Impacts of Standardisation and Data Handling within the Machine tool Service Environment [PDF]
The advance of modern machine tools has created the situation where the traditional approaches to machine tool measurement and reporting are beginning to fall short. Due to the large number of measurements required to fully qualify a complex machine tool,
Perkins, Christopher
core
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
New optical sensing system applied to taut wire based straightness measurement [PDF]
In modern manufacturing industry, precision components are typically produced on Computer Numerical Controlled (CNC) machine tools which translate their accuracy onto machined parts. This accuracy is affected by a set of different motion errors caused by
Borisov, Oleg
core
Comparative study of ANN and ANFIS prediction models for thermal error compensation on CNC machine tools [PDF]
, 2013 Thermal errors can have significant effects on CNC machine tool accuracy. The errors usually come from thermal deformations of the machine elements created by heat sources within the machine structure or from ambient change.
Longstaff, Andrew P. +3 more
core