Results 131 to 140 of about 1,399,412 (310)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Electronic based accuracy enhancement of CNC machine tools [PDF]
The need for better machine tool accuracy is discussed together with the factors which can affect machine tool accuracy. A study is made of the various techniques adopted for the reduction of errors in machine tools. The concept of error compensation
Postlethwaite, Scott R.
core
The significance of air pockets for modelling thermal errors of machine tools [PDF]
, 2013 It is well known, especially with the prevalence of compensation for geometric errors, that thermal error represents the most significant proportion of the total volumetric error of the machine tool. Thermal error in machine tools originates from changes
Longstaff, Andrew P. +5 more
core
Geometric Feature-Based Partial Retrieval of On-Machine Measurement Models
IEEE AccessTo realize the effective reuse of the existing model measurement process planning and to improve the efficiency of the preparation of the measurement program, this paper proposes an on-machine measurement model partial retrieval method based on geometric
Ying Xiang, Yi-Tao Fan, Zhong-Bao Liu
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Defining and Computing Machine Tool Accuracy [PDF]
, 2009 Understanding machine tool performance is important for specifying or comparing machines and for determining capability for production. Machine accuracy has generally been described by the linear positioning accuracy and repeatability of the axes.
Longstaff, Andrew P. +2 more
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Construction of Machine Tool Calibration Plans Using Domain-Independent Automated Planning [PDF]
The evolution in precision manufacturing has resulted in the requirement to produce and maintain more accurate machine tools. This new requirement coupled with desire to reduce machine tool downtime places emphasis on the calibration procedure during ...
Parkinson, Simon
core
A particle swarm optimisation-based Grey prediction model for thermal error compensation on CNC machine tools [PDF]
, 2015 Thermal errors can have a significant effect on CNC machine tool accuracy. The thermal error compensation system has become a cost-effective method of improving machine tool accuracy in recent years.
Longstaff, Andrew P. +3 more
core
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source