Results 71 to 80 of about 69,107,912 (284)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Applied Sciences, 2020 The position error of two parallel surfaces is generally constrained by parallelism. However, as a range of change, it cannot represent the positional relation between two parallel surfaces.
Zechen Lu +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Measuring Sentiment Bias in Machine Translation
, 2023 Biases induced to text by generative models have become an increasingly large topic in recent years. In this paper we explore how machine translation might introduce a bias in sentiments as classified by sentiment analysis models. For this, we compare three open access machine translation models for five different languages on two parallel corpora to ...
Kai Hartung +6 more
openaire +3 more sources
Development of an optical probe for evaluation of tool edge geometry
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 This paper proposes a non-contact and on-machine measurement method for evaluating tool edge geometry. In the proposed method, a focused laser beam having a diameter of several micrometres traces over the tool edge.
SungHo JANG +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A machine-to-machine architecture to merge semantic sensor measurements [PDF]
Proceedings of the 22nd International Conference on World Wide Web, 2013 The emerging field Machine-to-Machine (M2M) enables machines to communicate with each other without human intervention. Existing semantic sensor networks are domain-specific and add semantics to the context. We design a Machine-to-Machine (M2M) architecture to merge heterogeneous sensor networks and we propose to add semantics to the measured data ...
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Setup for Triggering Force Testing of Touch Probes for CNC Machine Tools and CMMs
Measurement Science Review, 2013 Touch-trigger probes are commonly used both in coordinate measuring machines (CMM) and in computer numerical control (CNC) machine tools. In both cases accuracy of measurement of the overall system and probing unit are closely interrelated.
Wozniak A., Byszewski M., Jankowski M.
doaj +1 more source