Results 91 to 100 of about 67,240,934 (242)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

DLR’s Advanced Telerobotic Concepts and Experiments for On-Orbit Servicing [PDF]

, 2007
Summary. Space robotics will become a key technology for the exploration of outer space and the operation and maintenance of space stations, satellites and other plat-forms, saving costs and relieving man from dangerous tasks.
Hirzinger, Gerd, Landzettel, Klaus, Reintsema, Detlef, Klaus L, Gerd Hirzinger, Detlef Reintsema   +5 more
core  

Rendezvous Simulation for On-Orbit Servicing Missions Using Advanced Robotic Technology [PDF]

, 2013
Increasing complexity and costs of satellite missions promote the idea of extending the operational lifetime or improving functionalities/performance of a satellite in orbit instead of simply replacing it by a new one.
Boge, Toralf, Benninghoff, Heike
core   +1 more source

Robust Onboard Orbit Determination Through Error Kalman Filtering

Aerospace
Accurate and robust on-board orbit determination is essential for enabling autonomous spacecraft operations, particularly in scenarios where ground control is limited or unavailable.
Michele Ceresoli, Andrea Colagrossi, Stefano Silvestrini, Michèle Lavagna   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Research of Design and Control System of Grab Mechanism of On-orbit Assembly Robot

Jixie chuandong, 2019
According to the requirement of the key technology research mission of on-orbit assembly space telescope and in order to implement the on-orbit assembly service effectively，the ground verification scheme of the on-orbit assembly robot and sub-mirror ...
Jiaqi Zhu, Hasiaoqier Han, Peng Yu, Kang Han, Qingwen Wu   +4 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source