0589 Dose Titration of Once-Nightly Sodium Oxybate: Analysis of Interim Data From RESTORE
Abstract Introduction FT218 (LUMRYZ™) is an investigational once-nightly sodium oxybate (ON-SXB) for treatment of adults with narcolepsy type 1 (NT1) or type 2 (NT2). The efficacy and safety of ON-SXB at doses 6, 7.5, and 9 g in patients with NT1/NT2 were confirmed in the phase 3 REST-ON clinical ...
Asim Roy +5 more
openaire +2 more sources
0579 Long-Term Safety of Once-Nightly Oxybate for Narcolepsy: RESTORE Study Interim Analysis of Data
Abstract Introduction The pivotal phase 3 REST-ON trial (NCT02720744) evaluated the efficacy and safety of once-nightly sodium oxybate (ON-SXB; FT218), an investigational extended-release formulation for treatment of adults with narcolepsy. In REST-ON, ON-SXB met its 3 coprimary endpoints: improvement
Thomas Stern +7 more
openaire +2 more sources
Exploratory clinical and urodynamic changes associated with mirabegron-containing multimodal treatment in children with non-monosymptomatic nocturnal enuresis: a retrospective real-world study [PDF]
BackgroundEvidence regarding mirabegron-containing treatment for children with non-monosymptomatic nocturnal enuresis (NMNE) is limited, and its independent effects require controlled evaluation.ObjectiveTo describe exploratory clinical and urodynamic ...
Zhenxian Cai +3 more
doaj +2 more sources
KeYProject/key: Nightly Release
<p><strong>Full Changelog</strong>: https://github.com/KeYProject/key/compare/KeY-2.4.0...nightly</p ...
mi.ki +27 more
core +6 more sources
Eosinophilic cystitis refractory to multiple treatments with good response to benralizumab: case report [PDF]
BackgroundEosinophilic cystitis is a rare inflammatory bladder disorder characterized by eosinophilic infiltration of the bladder wall. It frequently mimics infectious, inflammatory, or malignant conditions, and its management remains challenging due to ...
Marina Ruiz de Galarreta Beristain +11 more
doaj +2 more sources
Narcolepsy is associated with disrupted nighttime sleep (DNS). Sodium oxybate (SXB; Xyrem®), administered twice nightly, is indicated for the treatment of cataplexy and excessive daytime sleepiness in patients 7 years or older with narcolepsy.
Russell Rosenberg +5 more
doaj +1 more source
Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence.
Rashmi Singh, Shyam Sundar Pandey
doaj +3 more sources
‘I love you’: the first phrase detected from dreams [PDF]
Objective: Many people have dreams nightly and some maintain consciousness during dreams. Such dreams are referred to as lucid dreams (LD). During dreams, our speech correlates with facial muscle activity, which is hard to decode, but LD could solve this
Michael Raduga
doaj +1 more source
Foraging movements are density-independent among straw-coloured fruit bats [PDF]
Intraspecific competition in large aggregations of animals should generate density-dependent effects on foraging patterns. To test how large differences in colony size affect foraging movements, we tracked seasonal movements of the African straw-coloured
María C. Calderón-Capote +5 more
doaj +1 more source
0411 Once-Nightly Sodium Oxybate Dose Titration and Tolerability: Interim Data From RESTORE
Abstract Introduction Extended-release, once-nightly sodium oxybate (ON-SXB; FT218) is under FDA review for the treatment of adults with narcolepsy. RESTORE, an ongoing, open-label extension/switch study (NCT04451668), evaluates long-term ON-SXB safety and tolerability.
Asim Roy +6 more
openaire +2 more sources

