Results 21 to 30 of about 250 (109)
Implication of the thalamus in sleep alterations observed in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is frequently accompanied by sleep disturbances. Alterations of sleep, in both quality and quantity, contribute to the progression of AD neuropathology. The thalamus, through its diverse nuclei, plays a central role in sleep regulation and sleep‐dependent memory ...
Carla Burnet‐Merlin +2 more
wiley +1 more source
Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review
Brain and Behavior, Volume 15, Issue 12, December 2025.This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Natasha Elaine Hastings +12 more
wiley +1 more source
Narcolepsy 2025 (with an Australasian perspective)
Internal Medicine Journal, Volume 55, Issue 11, Page 1805-1813, November 2025.Abstract Narcolepsy is a disorder of central hypersomnolence, which, while uncommon, can carry profound implications for affected individuals. Despite this, it remains under‐recognised within the medical community and presents frequent diagnostic and treatment challenges in the Australasian setting.
Amelia Lin +3 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 10, October 2025.Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf +9 more
wiley +1 more source
The Space–Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5–1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp.
Mahmoud Alipour +5 more
wiley +1 more source
Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash +5 more
wiley +1 more source
Sleep Medicine—What's in a Name?
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence‐based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well‐being.
Dirk A. Pevernagie +7 more
wiley +1 more source
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.Abstract Background Recent studies have shown that sleep disturbances are frequent at different stages of psychosis, including clinical high risk for psychosis (CHR‐P). However, the comorbidity of hypersomnia with CHR‐P and its treatment have rarely been reported or discussed.
Yutaro Sato +2 more
wiley +1 more source
Rapid eye movement sleep muscle activity in routine polysomnography as a marker for narcolepsy
Sleep Research, Volume 2, Issue 2, Page 114-123, June 2025.Abstract Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and associated symptoms, including cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disrupted nocturnal sleep. It is classified into two subtypes: narcolepsy type 1 (NT1), which involves cataplexy and/or low cerebrospinal fluid ...
Dhirendra Paudel, Yan Xu, Bin Zhang
wiley +1 more source
Journal of Sleep Research, Volume 34, Issue 3, June 2025.In a cohort of central disorders of hypersomnolence, specifically women with idiopathic hypersomnia showed a marked subjective daytime sleepiness peak in the early 30s, while the body mass index only started to rise at that age. Better understanding of the pathophysiology of these gender and age‐specific characteristics will support tailored ...
Laura Ferrazzini +31 more
wiley +1 more source