Results 41 to 50 of about 1,677,629 (133)

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema   +9 more
wiley   +1 more source

The Space–Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5–1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp.
Mahmoud Alipour, Joseph Rausch, Sara C. Mednick, Jesse D. Cook, David T. Plante, Paola Malerba   +5 more
wiley   +1 more source

Pharmacokinetics and dose proportionality of FT218, an investigational controlled release formulation of sodium oxybate for once nightly dosing

, 2019
Introduction: Sodium oxybate is indicated for the treatment of Excessive Daytime Sleepiness (EDS) and cataplexy in patients with narcolepsy. The currently marketed product, an immediate release (IR) sodium oxybate, is required to be taken twice nightly ...
Monteith, D, Roth, Thomas, Grassot, J, Castellan, C   +3 more
core   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Sleep Medicine—What's in a Name?

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence‐based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well‐being.
Dirk A. Pevernagie, Erna Sif Arnardottir, Oliviero Bruni, Sarah Hartley, Gert Jan Lammers, Tiina Paunio, Dieter Riemann, Renata L. Riha   +7 more
wiley   +1 more source

Treatment of idiopathic hypersomnia with modafinil in an individual at clinical high risk for psychosis: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.
Abstract Background Recent studies have shown that sleep disturbances are frequent at different stages of psychosis, including clinical high risk for psychosis (CHR‐P). However, the comorbidity of hypersomnia with CHR‐P and its treatment have rarely been reported or discussed.
Yutaro Sato, Atsushi Sakuma, Hiroaki Tomita   +2 more
wiley   +1 more source

Rapid eye movement sleep muscle activity in routine polysomnography as a marker for narcolepsy

Sleep Research, Volume 2, Issue 2, Page 114-123, June 2025.
Abstract Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and associated symptoms, including cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disrupted nocturnal sleep. It is classified into two subtypes: narcolepsy type 1 (NT1), which involves cataplexy and/or low cerebrospinal fluid ...
Dhirendra Paudel, Yan Xu, Bin Zhang
wiley   +1 more source

Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
In a cohort of central disorders of hypersomnolence, specifically women with idiopathic hypersomnia showed a marked subjective daytime sleepiness peak in the early 30s, while the body mass index only started to rise at that age. Better understanding of the pathophysiology of these gender and age‐specific characteristics will support tailored ...
Laura Ferrazzini, Markus Schmidt, Zhongxing Zhang, Ramin Khatami, Yves Dauvilliers, Lucie Barateau, Geert Mayer, Fabio Pizza, Giuseppe Plazzi, Jari K. Gool, Rolf Fronczek, Gert Jan Lammers, Rafael del Rio‐Villegas, Rosa Peraita‐Adrados, Markku Partinen, Sebastiaan Overeem, Karel Sonka, Joan Santamaria, Raphael Heinzer, Francesca Canellas, Antonio Martins da Silva, Birgit Högl, Christian Veauthier, Aleksandra Wierzbicka, Eva Feketeova, Jitka Buskova, Michel Lecendreux, Silvia Miano, Ulf Kallweit, Anna Heidbreder, Claudio L. A. Bassetti, Julia van der Meer   +31 more
wiley   +1 more source

International Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (iSPHYNCS): the impact of psychiatric comorbidities on daily life in central disorders of hypersomnolence—a vicious circle

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary Presence of psychiatric comorbidities is well documented in narcolepsy type‐1 (NT1) but there are limited data on patients with ‘other central disorders of hypersomnolence’ (OCH). This study aimed to investigate frequency of psychiatric comorbidities in patients with NT1 and OCH, and to evaluate their impact on quality of life and sleep as an ...
Merve Aktan Suzgun, Elena S. Wenz, Julia van der Meer, Livia G. Fregolente, Jan D. Warncke, Silvia Miano, Jens Acker, Mathias Strub, Elisabeth Olliges, Ramin Khatami, Markus H. Schmidt, iSPHYNCS Investigators, Claudio L. A. Bassetti, Sigrid von Manitius   +13 more
wiley   +1 more source

The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1

Journal of Sleep Research, Volume 34, Issue 1, February 2025.
Summary Hypersomnia spectrum disorders are underdiagnosed and poorly treated due to their heterogeneity and absence of biomarkers. The electroretinography has been proposed as a proxy of central dysfunction and has proved to be valuable to differentiate certain psychiatric disorders.
Héloïse Rach, Ulker Kilic‐Huck, Pierre A. Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgin   +10 more
wiley   +1 more source