Results 41 to 50 of about 377 (154)

Narcolepsy 2025 (with an Australasian perspective)

Internal Medicine Journal, Volume 55, Issue 11, Page 1805-1813, November 2025.
Abstract Narcolepsy is a disorder of central hypersomnolence, which, while uncommon, can carry profound implications for affected individuals. Despite this, it remains under‐recognised within the medical community and presents frequent diagnostic and treatment challenges in the Australasian setting.
Amelia Lin, Brendon J Yee, Jian Eu Tai, Sheila Sivam   +3 more
wiley   +1 more source

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema   +9 more
wiley   +1 more source

The Space–Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5–1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp.
Mahmoud Alipour, Joseph Rausch, Sara C. Mednick, Jesse D. Cook, David T. Plante, Paola Malerba   +5 more
wiley   +1 more source

The effect and safety of sleep interventions on suicidal thoughts and behavior – A systematic review and meta-analyses [PDF]

Background: Sleep disturbances are a risk factor for suicidal ideation, suicide attempts and suicide. While recent findings suggest that improving sleep by psychotherapeutic sleep interventions exerts a positive effect on suicidality, there are also ...
Antypa, Niki, Heering, Henriette D., Katuin, Patricia, Kivelä, Liia, Lancel, Marike, Planting, Caroline, Schouten, Daan, Schweren, Lizanne J.S., von Spreckelsen, Paula, Waslam, Natasha G.   +9 more
core   +1 more source

Optimizing pain management and functional ability in the adolescent with chronic pain [PDF]

, 2023
Pain during childhood is a disruptive experience. Approximately 25% of children nationally experience chronic pain with 5-8% of them experiencing clinically disabling pain.
Firestone, Kari
core   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Is Pitolisant Effective in Reducing Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy? [PDF]

, 2019
Objective: The objective of this selective EBM review is to determine whether or not pitolisant is effective in reducing excessive daytime sleepiness and cataplexy in adults with narcolepsy.
Michael, Christina M
core   +1 more source

Sleep Medicine—What's in a Name?

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence‐based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well‐being.
Dirk A. Pevernagie, Erna Sif Arnardottir, Oliviero Bruni, Sarah Hartley, Gert Jan Lammers, Tiina Paunio, Dieter Riemann, Renata L. Riha   +7 more
wiley   +1 more source

Treatment of idiopathic hypersomnia with modafinil in an individual at clinical high risk for psychosis: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.
Abstract Background Recent studies have shown that sleep disturbances are frequent at different stages of psychosis, including clinical high risk for psychosis (CHR‐P). However, the comorbidity of hypersomnia with CHR‐P and its treatment have rarely been reported or discussed.
Yutaro Sato, Atsushi Sakuma, Hiroaki Tomita   +2 more
wiley   +1 more source

Rapid eye movement sleep muscle activity in routine polysomnography as a marker for narcolepsy

Sleep Research, Volume 2, Issue 2, Page 114-123, June 2025.
Abstract Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and associated symptoms, including cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disrupted nocturnal sleep. It is classified into two subtypes: narcolepsy type 1 (NT1), which involves cataplexy and/or low cerebrospinal fluid ...
Dhirendra Paudel, Yan Xu, Bin Zhang
wiley   +1 more source