Results 11 to 20 of about 846,916 (323)

SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion

Experimental Hematology & Oncology, 2021
Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and ...
Shu Yang, Hongying Zhang, Hua Yang, Jin Zhang, Jiao Wang, Ting Luo, Yangfu Jiang, Hui Hua   +7 more
doaj   +1 more source

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., John, J., Sendtner, M., Wittinghofer, A.   +5 more
core   +2 more sources

Targeting Akt in cancer for precision therapy

Journal of Hematology & Oncology, 2021
Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatment.
Hui Hua, Hongying Zhang, Jingzhu Chen, Jiao Wang, Jieya Liu, Yangfu Jiang   +5 more
doaj   +1 more source

Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women

Cancer Biology & Medicine, 2022
Objective: This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.
Xiaowei Ji, Jing Wang, Zhuoying Li, Qiuming Shen, Jiayi Tuo, Jinghao Bi, Yuting Tan, Honglan Li, Yongbing Xiang   +8 more
doaj   +1 more source

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

Journal of Hematology & Oncology, 2020
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in ...
Hui Hua, Qingbin Kong, Jie Yin, Jin Zhang, Yangfu Jiang   +4 more
doaj   +1 more source

Correction: MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8 [PDF]

Scientific Reports
Minyu Wang, Jilin Wang, Xuan Kong, Huimin Chen, Yingchao Wang, Miao Qin, Yanwei Lin, Haoyan Chen, Jie Xu, Jie Hong, Ying-Xuan Chen, Weiping Zou, Jing-Yuan Fang   +12 more
doaj   +2 more sources

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer [PDF]

, 2017
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative ...
Andersen, Jesper B., Arricibita, Andrea, Bailey, Peter, Biankin, Andrew, Bozec, Aline, Chang, David K., Chuang, Chen-Hua, Guembe, Laura, Guruceaga, Elisabet, Gwinn, Dana, Khatri, Purvesh, Lecanda, Fernando, Martinez-Canarias, Susana, Mazur, Pawel K., Perurena, Naiara, Ponz-Sarvise, Mariano, Sage, Julien, Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Valencia, Karmele, Vallejo, Adrian, Vicent, Silve, Zandueta, Carolina   +22 more
core   +3 more sources

Oncogenes

Scandinavian Journal of Gastroenterology, 1985
The central problem in cancer therapy is the poor selectivity of current systemic agents against the common solid tumours. The demonstration that unique segments of DNA, constant in location and conserved in evolution are involved in growth control opens new avenues for basic and clinical research.
  +8 more sources

Mechanisms for estrogen receptor expression in human cancer

Experimental Hematology & Oncology, 2018
Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
Hui Hua, Hongying Zhang, Qingbin Kong, Yangfu Jiang   +3 more
doaj   +1 more source

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Journal of Hematology & Oncology, 2022
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang, Hongying Zhang, Jiao Wang, Yongliang Liu, Ting Luo, Hui Hua   +5 more
doaj   +1 more source