Results 41 to 50 of about 657,003 (258)
, 2005 Review on VAV1 (vav 1 oncogene), with data on DNA, on the protein encoded, and where the gene is ...
Katzav, S
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
, 2017 (A) Venn diagram shows 7 up-regulated and 23 down-regulated DEGs related to oncogenes. (B) Gene expression profiles of representative differently expressed oncogenes.
Sangho Roh (3813019) +2 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
, 1998 Review on DEK (DEK oncogene), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Deep attention based Proto-oncogene prediction and Oncogene transition possibility detection using moments and position based amino acid features [PDF]
The loss of the regulatory function of tumor suppression genes and mutations in Proto-oncogene are the common underlying mechanisms for uncontrolled tumor growth in the varied complex of disorders known as cancer.
M. Vallinayagi, M. Vijayalakshmi
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mechanism of met Oncogene Activation
, 1986 The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell line with N-methyl-N′-nitronitrosoguanidine (MNNG) is related to the tyrosine kinase gene family.
Schmidt, Martin +7 more
core +1 more source
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Nature Communications, 2017 Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang +12 more
doaj +1 more source