Results 61 to 70 of about 657,003 (258)

The impact of Mir-9 regulation in normal and malignant hematopoiesis

Oncology Reviews, 2018
MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined.
Abbas Khosravi, Shaban Alizadeh, Arsalan Jalili, Reza Shirzad, Najmaldin Saki   +4 more
doaj   +1 more source

Anti-c-myc RNAi-Based Onconanotherapeutics

Biomedicines, 2020
Overexpression of the c-myc proto-oncogene features prominently in most human cancers. Early studies established that inhibiting the expression of oncogenic c-myc, produced potent anti-cancer effects.
Saffiya Habib, Mario Ariatti, Moganavelli Singh   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer.

, 2013
B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes.
Massoumi, Ramin, Saamarthy, Karunakar, Bjartell, Anders, Ahlqvist, Kristofer, Syed Khaja, A S, Saamarthy, Karunakar,, Massoumi, Ramin,, Bjartell, Anders,, Ahlqvist, Kristofer,, Lund University.   +9 more
core   +1 more source

The role of the proto-oncogene Ski in cortical development [PDF]

, 2013
The proto-oncogene Ski is an evolutionary conserved protein associated with various cellular processes such as proliferation and differentiation as well as transformation and tumor progression.
Baranek, Constanze Katharina Charlotte
core   +1 more source

MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8

Scientific Reports, 2014
In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation with lymph node invasion, distant metastasis and patient survival in ...
Minyu Wang, Jilin Wang, Xuan Kong, Huimin Chen, Yingchao Wang, Miao Qin, Yanwei Lin, Haoyan Chen, Jie Xu, Jie Hong, Ying-Xuan Chen, Weiping Zou, Jing-Yuan Fang   +12 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis.

, 1996
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells.
Peli, J., Erny, K.M., Muller, V., Lambert, J.F., Diggelmann, H.   +4 more
core  

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia [PDF]

, 2017
Correction to: Oncogene (2018) 37, 1062–1074; doi: 10.1038/onc.2017.368; published online 6 November 2017 This article was originally published under NPG's License to Publish, but has now been made available under a CC BY license.
Meng, Y-T, W-X Lin, E W-F Lam, J-H Wang, F An, Liu, Q, B Cui, Wang, H-F, Lv, L, Peng, F, W-J Fan, Wang, J-H, Y-T Meng, H-F Wang, Liu, X-F, J Xu, M-M Li, Guo, T, Xu, J, Lv, D-K, L-Z Xu, Zhao, Y, L Lv, Li, M-M, L Zhang, Cui, B, J-J Xie, An, F, Lin, W-X, Li, T-T, Q Liu, D-K Lv, Xu, L-Z, Y Zhao, X-F Liu, Fan, W-J, Lam, EW-F, F Peng, Xie, J-J, T-T Li, Zhang, L, T Guo   +41 more
core   +1 more source