Results 221 to 230 of about 577,954 (290)

Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification. [PDF]

Nat Struct Mol Biol
Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Zhao T, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Tackett AJ, Wang Y, Song J, Politi K, Wang S, Xiao AZ.   +19 more
europepmc   +1 more source

The Effects of 1.25-dihydroxyvitamin D on HIF-1a Expression In Breast Epithelial Cells Containing the ErbB2 Oncogene

, 2009
Jessica Harris
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Biomarker analysis from a Phase 1/1b study of tusamitamab ravtansine in patients with advanced non-small cell lung cancer. [PDF]

Transl Oncol
Gazzah A, Ternès N, Lee JS, Wang E, Carene D, Wang H, Masson N, Boitier E, Lartigau A, Mace N, Chadjaa M, Dib C, Nunes M, Muzard G, Longuemaux-Valence S, Bauchet AL.   +15 more
europepmc   +1 more source

Additional file 4: Figure S4. of MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway

, 2015
Xuewei Xia, Yong Li, Wenbo Wang, Fang Tang, Jie Tan, Liyuan Sun, Qinghua Li, Li Sun, Bo Tang, Songqing He   +9 more
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Prevalence, molecular characterization, and prognosis of c-Met protein overexpression in a real-world cohort of patients with non-squamous non-small cell lung cancer. [PDF]

Acta Oncol
Bar J, Cai MH, Choi YC, Baijal S, Zhao W, Liede A, Vasilopoulos A, Roberts-Rapp L, Jiang F, Simmons A, Ratajczak C, Lu S, Ansell PJ, Camidge DR.   +13 more
europepmc   +1 more source

Targeted Delivery of Small Interfering RNA (siRNA) Against Oncogenes by using pH-Sensitive Nanoparticles to Inhibit Breast Cancer Cells Proliferation and Survival

, 2017
Nur Izyani Kamaruzman
openalex   +2 more sources

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

<i>RSPO3</i> rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. [PDF]

World J Gastrointest Oncol
Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM.   +6 more
europepmc   +1 more source