Results 41 to 50 of about 696,036 (402)

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

Nature, 2017
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood.
Kristen M. Turner, Viraj Deshpande, Doruk Beyter, Tomoyuki Koga, Jessica M. Rusert, Catherine Lee, Bin Li, K. Arden, B. Ren, D. Nathanson, H. Kornblum, H. Kornblum, Michael D. Taylor, S. Kaushal, W. Cavenee, R. Wechsler-Reya, F. Furnari, S. Vandenberg, P. Rao, G. Wahl, V. Bafna, P. Mischel   +21 more
semanticscholar   +1 more source

Reviewing Oncogenes and Proto-Oncogenes

International Journal of Scientific Research in Science and Technology, 2021
This article is an examination of the Reviewing oncogenes and Proto-oncogenes The scientific development and subsequent “oncogenes and Proto-oncogenes” continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists.
Nehal Batra, Ishita Ghag, Karishma Babu, Tejaswini Divanji   +3 more
openaire   +2 more sources

Reprogramming normal cells into tumor precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

Nature Materials, 2020
Defining the interplay between the genetic events and microenvironmental contexts necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology.
T. Panciera, Anna Citron, Daniele Di Biagio, G. Battilana, A. Gandin, S. Giulitti, M. Forcato, S. Bicciato, Valeria Panzetta, S. Fusco, L. Azzolin, A. Totaro, A. D. Dei Tos, M. Fassan, V. Vindigni, F. Bassetto, A. Rosato, G. Brusatin, M. Cordenonsi, S. Piccolo   +19 more
semanticscholar   +1 more source

Application Progress of Immune Checkpoint Inhibitors 
in Oncogene-driven Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2021
With the development of precise medicine, targeted therapy has greatly improved the survival and prognosis of patients in advanced non-small cell lung cancer (NSCLC) with oncogenic drivers.
Tongmei ZHANG, Baolan LI
doaj   +1 more source

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism [PDF]

, 2012
Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation.
Abraham, Ackermann, Ang Li, Balch, Balch, Bauer, Buccione, Cook, Demunter, Downward, Edward, Fuchs, Furmaniak-Kazmierczak, Gray-Schopfer, Hancock, Hendrix, Hirobe, Jaffe, Karen Blyth, Karreth, Kelsh, Kissil, Kunisada, Larue, Laura M. Machesky, Li, Li, Linder, Lionel Larue, Luciani, Mackenzie, Malumbres, Marshall, McCalmont, Meng Jin, Mishra, Mort, Nakahara, Owen J. Sansom, Peters, Platz, Qiu, Richard L. Mort, Sahai, Samuel, Scott, Sharov, Susan Mason, Vidali, Whitwam, Yafeng Ma, Yamaguchi, Yang   +52 more
core   +1 more source

EcDNA hubs drive cooperative intermolecular oncogene expression

bioRxiv, 2020
Extrachromosomal DNAs (ecDNAs) are prevalent in human cancers and mediate high oncogene expression through elevated copy number and altered gene regulation1.
King L. Hung, K. Yost, Liangqi Xie, Quanming Shi, K. Helmsauer, J. Luebeck, R. Schöpflin, Joshua T. Lange, R. Chamorro González, Natasha E Weiser, Celine Y. Chen, Maria E. Valieva, I. Wong, Sihan Wu, S. R. Dehkordi, Connor V. Duffy, K. Kraft, Junfang Tang, J. Belk, John C. Rose, M. Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, A. Bagchi, Ansuman T. Satpathy, R. Tjian, S. Mundlos, V. Bafna, A. Henssen, P. Mischel, Zhe J. Liu, Howard Y. Chang   +33 more
semanticscholar   +1 more source

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]

, 2020
The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua, Kirkemo, Lisa, Leung, Kevin, Riley, Nicholas, Wells, James, Wilson, Gary   +5 more
core  

PVT1: a rising star among oncogenic long non-coding RNAs [PDF]

, 2015
It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function.
Colombo, Teresa, Farina, Lorenzo, Macino, Giuseppe, Paci, Paola   +3 more
core   +4 more sources

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Nature, 2011
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor ...
G. DeNicola, F. Karreth, Timothy J. Humpton, A. Gopinathan, Cong Wei, K. Frese, Dipti Mangal, Kenneth H. Yu, C. Yeo, E. Calhoun, F. Scrimieri, J. Winter, R. Hruban, C. Iacobuzio-Donahue, S. Kern, I. Blair, D. Tuveson   +16 more
semanticscholar   +1 more source