Results 81 to 90 of about 696,036 (402)

Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. [PDF]

, 2009
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene.
Albertson, DG, Connelly, ST, Huey, B, Jordan, RCK, Roy, R, Schmidt, BL, Snijders, AM   +6 more
core  

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2017
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source

Emerging roles of i-motif in gene expression and disease treatment

Frontiers in Pharmacology, 2023
As non-canonical nucleic acid secondary structures consisting of cytosine-rich nucleic acids, i-motifs can form under certain conditions. Several i-motif sequences have been identified in the human genome and play important roles in biological regulatory
Xiaoqing Luo, Jianye Zhang, Yue Gao, Weifei Pan, Yayuan Yang, Xu Li, Lingfei Chen, Chang Wang, Yuqing Wang   +8 more
doaj   +1 more source

TAF2: A potential oncogene for hepatocellular carcinoma [PDF]

, 2017
Astrocyte Elevated Gene 1 (AEG1) is an oncogene for hepatocellular carcinoma (HCC). Its role in HCC pathogenesis has been well studied. A pan cancer analysis of gene expression in multiple databases identified TATA-box binding protein associated factor 2
Chidambaranathan Reghupaty, Saranya
core   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

PELP1 Suppression Inhibits Gastric Cancer Through Downregulation of c-Src-PI3K-ERK Pathway

Frontiers in Oncology, 2020
Background: Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a co-activator of estrogen receptors alpha, was confirmed to be directly associated with the oncogenic process of multiple cancers, especially hormone-dependent cancers.
Hongzhu Yan, Hongzhu Yan, Yanling Sun, Qian Wu, Zhe Wu, Meichun Hu, Yuanpeng Sun, Yusi Liu, Zi Ma, Shangqin Liu, Wuhan Xiao, Fuxing Liu, Zhifeng Ning   +12 more
doaj   +1 more source

Variance function estimation in quantitative mass spectrometry with application to iTRAQ labeling [PDF]

Annals of Applied Statistics 2013, Vol. 7, No. 1, 1-24, 2013
This paper describes and compares two methods for estimating the variance function associated with iTRAQ (isobaric tag for relative and absolute quantitation) isotopic labeling in quantitative mass spectrometry based proteomics. Measurements generated by the mass spectrometer are proportional to the concentration of peptides present in the biological ...
arxiv   +1 more source

TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]

, 2016
E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH, He, YY, Qiang, L, Shah, P   +3 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source