Results 271 to 280 of about 369,580 (326)

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Novel SMARCA2::DDIT3 Fusion in Primary Subcutaneous Myxoid Liposarcoma due to an Unusual Unbalanced Chromosomal Translocation. [PDF]

Genes Chromosomes Cancer
Shah A, Shah A, Sukov WR, Halling K, Marcelis L, Oliveira A.   +5 more
europepmc   +1 more source

Dermatologic Features of Endocrine Tumor Syndromes—Systematic Review and Meta‐Analysis

International Journal of Dermatology, Volume 65, Issue 3, Page 464-488, March 2026.
ABSTRACT Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development.
Sára Pálla, Zseraldin Metyovinyi, Fanni Adél Meznerics, Arash Mirzahosseini, Judit Tőke, Miklós Tóth, Henriett Butz, Attila Patócs, Márta Medvecz   +8 more
wiley   +1 more source

Amino acid metabolic reprogramming: future prospects for cholangiocarcinoma therapy. [PDF]

Cell Death Discov
Hua S, Fei F, Li J, Liu Y, Gao Y, Wang X, Dong X, Liu Q, Yang J.   +8 more
europepmc   +1 more source

Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC)

International Journal of Cancer, Volume 158, Issue 4, Page 1080-1092, 15 February 2026.
What's new? Human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC) is suspected of originating from tonsillar crypts, where HPV can persist in latent form. Detection is further complicated by the possible absence of premalignant stages, namely carcinoma in situ (CIS). Here, the authors investigated tumor origin in HPV‐associated
Tobias Näsman, Madeleine Birgersson, Linda Marklund, Anders Näsman   +3 more
wiley   +1 more source

Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway. [PDF]

Viruses
Yang Y, Li X, Shi H, Yu J, Gao C, Liu Y, Feng W, Peng L, Fu B, Yi P.   +9 more
europepmc   +1 more source

Mild Short‐Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Rats under mild caloric restriction (85% vs. ad libitum) for 2 weeks show metabolic and structural adaptations in iBAT. Caloric restriction increases glycolysis and triglyceride deposition in the tissue, leading to larger lipid droplets. It also reduces mitochondrial iBAT content, while maintaining iBAT thermogenic potential thanks to an increased ...
Giuliana Panico, Vincenzo Migliaccio, Gabriella Pinto, Anna Iliano, Gianluca Fasciolo, Martina Coletta, Paola Venditti, Maria Moreno, Angela Amoresano, Pieter de Lange, Lillà Lionetti, Assunta Lombardi   +11 more
wiley   +1 more source

TFE3 fusion proteins promoted the progression of Xp11.2 translocation renal cell carcinoma through post-translational modification of PDL1 by upregulating CCND1/Cyclin D1. [PDF]

Cell Oncol (Dordr)
Lu Y, Chen Y, Pan X, Ma W, Liu N, Yang L, Dong X, Guo H, Li D, Gan W.   +9 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, Volume 16, Issue 2, Page 352-364, February 2026.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Regulation of autophagy by oncogene DJ1 via the JNK signaling pathway in human ovarian cancer cells. [PDF]

J Ovarian Res
Zhao XM, Wang K, Wang Z, Xie D, Liu H, Li P, Wang WM.   +6 more
europepmc   +1 more source