Results 31 to 40 of about 369,580 (326)
Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins [PDF]
Cancer Research, 2019 Abstract Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners.
Dana S. Neel +15 more
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Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion
BMC Cancer, 2019 Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-ros UR2 sarcoma virus oncogene ...
Koh Furugaki +5 more
doaj +1 more source
Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue
Autophagy Reports, 2023 Autophagy is a central process responsible for the disposal of normal as well as damaged cellular proteins and organelles. Proper regulation of multiple steps – including initiation and the fusion between autophagosomes and lysosomes – is essential for ...
Yungui Guo, Erika R. Geisbrecht
doaj +1 more source
E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]
, 2006 Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Adam +30 more
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Leukemia, 2010 ABL gene translocations create constitutively active tyrosine kinases that are causative in chronic myeloid leukemia, acute lymphocytic leukemia and other hematopoietic malignancies.
M. Thai +6 more
semanticscholar +1 more source
British Journal of Cancer, 2010 Background:Characterisation of EWS-Oct-4 translocation fusion product in bone and soft-tissue tumours revealed a chimeric gene resulting from an in-frame fusion between EWS (Ewing's sarcoma gene) exons 1–6 and Oct-4 exons 1–4.
S. Kim, B. Lim, J. Kim
semanticscholar +1 more source
Biomedical Journal, 2019 Protein tyrosine kinases (TKs) are a family of enzymes that catalyze the phosphorylation of proteins at tyrosine residues. TKs play key roles in controlling cell growth and many other functions by modulating the status of tyrosine phosphorylation of ...
Jau-Song Yu
doaj +1 more source
DRP1 Promotes BRAFV600E-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer
Frontiers in Oncology, 2021 BackgroundMitochondria are highly dynamic organelles which remain in a continuous state of fission/ fusion dynamics to meet the metabolic needs of a cell. However, this fission/fusion dynamism has been reported to be dysregulated in most cancers.
Rayees Ahmad Padder +4 more
doaj +1 more source
Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway [PDF]
Molecular Cancer, 2018 The insulin-like growth factor-1 receptor (IGF1R) has been identified as a potent anti-apoptotic, pro-survival tyrosine kinase-containing receptor. Overexpression of the IGF1R gene constitutes a typical feature of most human cancers. Consistent with these biological roles, cells expressing high levels of IGF1R are expected not to die, a quintessential ...
Haim Werner +2 more
openaire +3 more sources
Journal of Hepatology, 2021 About 15% of intrahepatic cholangiocarcinomas (iCCAs) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), usually alongside mutational inactivation of TP53, CDKN2A or BAP1. In FFs, FGFR2 residues 1-768 fuse to sequences encoded by a diverse array of partner genes (>60) causing oncogenic FF activation. While FGFR-specific tyrosine
Giulia Cristinziano +18 more
openaire +5 more sources