Results 61 to 70 of about 313,516 (269)

Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS

Nature Communications
Targeted protein degradation (TPD) has enabled modulation of previously undruggable proteins. However, existing small-molecule approaches require arduous optimization and are largely confined to targets bearing ligandable pockets.
Max M. Wang, Mihai I. Truica, Brayley S. Gattis, Julia Oktawiec, Vinay Sagar, Ananya A. Basu, Paul A. Bertin, Xiaoyu Zhang, Sarki A. Abdulkadir, Nathan C. Gianneschi   +9 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King, Amanda Midkiff, Karsyn McClain, Sanggu Kim, Amanda R. Panfil   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1) [PDF]

Journal of Biological Chemistry, 2011
Latent membrane protein 1 (LMP1), encoded by Epstein-Barr virus, is required for EBV-mediated B cell transformation and plays a significant role in the development of posttransplant B cell lymphomas. LMP1 has also been implicated in exacerbation of autoimmune diseases such as systemic lupus erythematosus.
Kelly M, Arcipowski, Laura L, Stunz, John P, Graham, Zachary J, Kraus, Tony J, Vanden Bush, Gail A, Bishop   +5 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Activation of the oncogenic miR‐21‐5p promotes HCV replication and steatosis induced by the viral core 3a protein

Liver International, 2019
AbstractBackground & aimsmiR‐21‐5p is a potent oncogenic microRNA targeting many key tumour suppressors including phosphatase and tensin homolog (PTEN). We recently identified PTEN as a key factor modulated by hepatitis C virus (HCV) to promote virion egress.
Sophie Clément, Cyril Sobolewski, Diana Gomes, Angela Rojas, Nicolas Goossens, Stéphanie Conzelmann, Nicolas Calo, Francesco Negro, Michelangelo Foti   +8 more
openaire   +4 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.

PLoS Biology, 2016
Microtubule-based kinesin motors have many cellular functions, including the transport of a variety of cargos. However, unconventional roles have recently emerged, and kinesins have also been reported to act as scaffolding proteins and signaling ...
Roberta Noseda, Marta Guerrero-Valero, Valeria Alberizzi, Stefano C Previtali, Diane L Sherman, Marilena Palmisano, Richard L Huganir, Klaus-Armin Nave, Ana Cuenda, Maria Laura Feltri, Peter J Brophy, Alessandra Bolino   +11 more
doaj   +1 more source

Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation. [PDF]

PLoS Pathogens, 2011
Natural killer (NK) cells are lymphocytes that play a major role in the elimination of virally-infected cells and tumor cells. NK cells recognize and target abnormal cells through activation of stimulatory receptors such as NKG2D.
Maria Tokuyama, Clarisse Lorin, Frederic Delebecque, Heiyoun Jung, David H Raulet, Laurent Coscoy   +5 more
doaj   +1 more source