Results 171 to 180 of about 635,296 (203)

Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
openaire   +2 more sources

G Protein Oncogenes

1991
This review will describe experiments aimed at answering two questions raised by the recent convergence of research on signal-transducing G proteins and oncogenes: What roles do individual G proteins play in normal regulation of cell proliferation? How do dominantly acting G protein oncogenes contribute to tumorigenesis, in experimental systems and in ...
openaire   +1 more source

Oncogenic mechanisms of Evi-1 protein

Cancer Chemotherapy and Pharmacology, 2001
Although Evi-1 is thought to promote growth or block differentiation in some cell types, its biological functions have not been elucidated. To explore the mechanisms underlying Evi-1-induced oncogenesis, we investigated whether Evi-1 affects the signaling of transforming growth factor beta (TGF-beta), which inhibits proliferation of a wide range of ...
H, Hirai, K, Izutsu, M, Kurokawa, K, Mitani   +3 more
openaire   +2 more sources

G protein oncogenes in pituitary tumors

Trends in Endocrinology & Metabolism, 1992
G proteins are involved in the transduction of external signals from cell surface receptors to intracellular effectors. Somatic mutations activating the a-subunit of G(s) (the stimulatory regulatory protein of adenylyl cyclase) by inhibiting its intrinsic GTPase activity have been first identified in human GH-secreting adenomas and subsequently found ...
A, Spada, L, Vallar, G, Faglia
openaire   +2 more sources

Potential oncogenic hazards posed by oncogene encoded proteins.

Developments in biological standardization, 1988
The theoretical risk from oncogene encoded proteins is limited to growth factors, which may be secreted by cells in which biologically derived products might be manufactured. Because these peptides do not replicate, their effect is finite. In addition, their effects are reversible. Growth factors do not ordinarily appear to be oncogenic.
openaire   +1 more source

Immunity to Oncogenic Proteins

Immunological Reviews, 1995
M A, Cheever, M L, Disis, H, Bernhard, J R, Gralow, S L, Hand, E S, Huseby, H L, Qin, M, Takahashi, W, Chen   +8 more
openaire   +2 more sources

Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment

Nature Reviews Drug Discovery, 2022
Giulia Petroni, Aitziber Buqué, Lisa Coussens   +2 more
exaly  

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

Nature Reviews Clinical Oncology, 2021
Renumathy Dhanasekaran, Anja Deutzmann, Dean W Felsher   +2 more
exaly  

The Proteins of Oncogenes

Scientific American, 1984
openaire   +2 more sources

Oncogenes and oncogene proteins.

Occupational medicine (Philadelphia, Pa.), 1987
P W, Brandt-Rauf, M R, Pincus
openaire   +1 more source