Results 111 to 120 of about 177,226 (290)

Specific Targeting of Oncogenes Using CRISPR Technology

, 2018
Oppel F, Schürmann M, Goon P, Albers AE, Sudhoff H. Specific Targeting of Oncogenes Using CRISPR Technology. Cancer Research.
Schürmann, Matthias, Sudhoff, Holger ; https://orcid.org/, Oppel, Felix, Goon, Peter, Albers, Andreas E.   +4 more
core   +1 more source

Editorial: Diverse roles of MAP4K4 in MAP kinase signaling and its implication for cancer therapeutics

Frontiers in Oncology, 2023
Ruchi Roy, Sunil Kumar Singh, Ajay Rana
doaj   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Activation of proto-oncogenes by disruption of chromosome neighborhoods

, 2016
Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we ...
Weintraub, Abraham Selby, Fan, Zi Peng, Li, Charles, Lajoie, Bryan R., Sigova, A. A., Young, Richard A., Dekker, J., Porteus, Matthew, Young, Richard, Sigova, Alla A., Li, Charles Han, Day, Daniel S., Li, Charles H., Day, Daniel, Porteus, Matthew H., Weintraub, Abraham, Jaenisch, Rudolf, Day, D. S., Weintraub, Abraham S., Lajoie, Bryan, Sigova, Alla, Borges-Rivera, Diego, Bak, R. O., Borges-Rivera, Diego Ramon, Valton, Anne-Laure, Valton, A.-L., Lee, Tong Ihn, Lajoie, B. R., Lee, T. I., Porteus, M. H., Dekker, Job, Reddy, Jessica, Goldmann, J., Goldmann, Johanna, Bak, Rasmus O., Hnisz, Denes, Bak, Rasmus, Hnisz, D.   +37 more
core   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Enrichment of oncogenes during the early time points.

, 2013
All upregulated DE genes at each time point (when compared to the zero hour control) were interrogated for being oncogenes by their presence in the Memorial Sloan Kettering Cancer Center Oncogene set (http://cbio.mskcc.org/CancerGenes/Select.action) and ...
Chris Barry (374156), Cynthia Alexander Rascón (386638), Jennifer M. Bolin (386644), Jeff Nie (5707), Hamisha Ardalani (386641), Ning Leng (386645), Mitchell D. Probasco (386643), Li-Fang Chu (386640), Ron Stewart (114673), Ryan J. Wagner (386642), Michael Volkmer (4850), Shulan Tian (386639), Srikumar Sengupta (259261), James A. Thomson (386646), Bianca Habermann (4847), Colin N. Dewey (257084), Elly M. Tanaka (228562)   +16 more
core   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Factores de crecimiento, receptores y oncogenes

, 2009
Factores de crecimiento, receptores y ...
Martín Zanca, Dionisio
core  

Evaluación del estado de amplificación de oncogenes, como marcadores moleculares en DNA libre en plasma de pacientes con cáncer pulmonar [PDF]

, 2014
En el cáncer se presentan distintos cambios en el genoma, la amplificación de oncogenes se ha descrito como una de las más frecuentes. Conocer la biología molecular del cáncer e identificar cambios moleculares comunes en la heterogeneidad del cáncer ...
Cruz Lozano, Yara
core