Results 241 to 250 of about 165,865 (302)

Fusion oncogenes in cancer: organoid models and novel therapeutic approaches. [PDF]

BMC Biol
Bracesco L, Hendriks D, Artegiani B.
europepmc   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Targeting super-enhancer-driven SKIL transcription by CDK7 inhibitor THZ1 to suppress gastric cancer progression. [PDF]

J Transl Med
Lan B, Zhou T, Pan L, Cui M, Tan Q, Pu T, Ran L, Wei S, Zhu X, Huang H.   +9 more
europepmc   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors. [PDF]

Signal Transduct Target Ther
Rai C, Ruan H, Li X, Li W, Jeong HH, Song C, Liu P, Chang Y, Fang H, Kumar S U, Sun Y, You MJ, Guan D, Liu Z, Han L, Hou X, Sun Z.   +16 more
europepmc   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

PICDGI: A framework for predicting cancer driver genes through dynamic gene-gene interaction modeling of single-cell data. [PDF]

PLoS Comput Biol
Atitey K, Anchang B.
europepmc   +1 more source

Let-7a and miR-34a Interplay Potent Suppressive Roles in Hepatocellular Carcinoma via Co-Targeting <i>FNDC3B</i>, <i>IGF2</i> and <i>SOX4</i>. [PDF]

Int J Mol Sci
Soliman B, Ibrahim AF, Salem A, Ghazy M, Abo-Elfadl MT, ElHefnawi M, Flores M.   +6 more
europepmc   +1 more source