Results 261 to 270 of about 250,918 (350)
Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future
Advanced Intelligent Systems, EarlyView.Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley +1 more source
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. [PDF]
, 1987 Annemarie Honegger +7 more
openalex +1 more source
Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type. [PDF]
iScienceLang JD +18 more
europepmc +1 more source
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé +5 more
wiley +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Animal Models and Experimental Medicine, EarlyView.BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen +5 more
wiley +1 more source
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
Angewandte Chemie, EarlyView.The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved +5 more
wiley +2 more sources
Metabolic pathways of Alternative Lengthening of Telomeres in pan-carcinoma. [PDF]
PLoS OneArmendáriz-Castillo I +12 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai +8 more
wiley +1 more source