Results 221 to 230 of about 80,296 (266)
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2015
This paper reviews current theories on the etiology of acquired immunodeficiency syndrome (AIDS) recent advances in the mechanisms of oncogenesis and the relationship of immunodeficiency to the development of cancer. It then attempts to synthesize these concepts into a hypothesis to explain the AIDS-cancer connection.
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This paper reviews current theories on the etiology of acquired immunodeficiency syndrome (AIDS) recent advances in the mechanisms of oncogenesis and the relationship of immunodeficiency to the development of cancer. It then attempts to synthesize these concepts into a hypothesis to explain the AIDS-cancer connection.
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Evolutionary maintenance of oncogenesis
Journal of Cancer Research and Clinical Oncology, 2008Transformation of normal cells into cells with malignant phenotypes is often the result of loss of tumor suppressor gene (TSG) function after exposure to a carcinogen.We propose that TSGs susceptible to mutation and consequent loss of function are evolutionarily preserved in normal cell genomes so that the cells survive mutation-inducing insults and ...
Steven M, Sorscher +2 more
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The Biology of Thyroid Oncogenesis
2009Over the past 20 years, our understanding of the molecular biology of thyroid cancer has advanced significantly. These new insights have in turn unleashed a vast potential for clinical application across the diagnostic, prognostic, and therapeutic spectrum.
Insoo, Suh, Electron, Kebebew
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On the molecular basis of oncogenesis
Journal of Theoretical Biology, 1981Abstract Among the non-histone nuclear proteins are a subgroup of control proteins which mediate cellular differentiation. By binding to multiple sites on the chromatin, these proteins repress fetal gene products, induce the expression of adult characteristics, and modulate the cell cycle by preventing the initiation of DNA synthesis.
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Genome instability and oncogenesis
Molecular Biology, 2007Molecular alterations leading to genetic instability play a key role in tumor development. The basic reasons of genetic instability of tumor cells, i.e. up-regulation of intracellular level of endogenous mutagens, in particular reactive oxygen spesies (ROS); decreased fidelity of DNA replication and chromosome segregation in mitosis; defects in DNA ...
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Chromosome Alterations in Oncogenesis
1985Recently there has been increased interest in the study of chromosomal alterations in neoplastic cells. Such investigations have already begun to contribute significantly to our understanding of fundamental tumor biology, particularly with respect to the role of specific genes in carcinogenesis.
P C, Nowell +4 more
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Current Opinion in Genetics & Development, 1993
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene ...
T, Motokura, A, Arnold
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The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene ...
T, Motokura, A, Arnold
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Cyclooxygenase-2 in oncogenesis
Clinica Chimica Acta, 2011Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2, the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and epidemiological data indicate that aberrant regulation of cyclooxygenase-2 in certain solid tumors and hematological malignancies is associated with adverse clinical outcome.
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Endosomal Signaling and Oncogenesis
2014The endosomal system provides a route whereby nutrients, viruses, and receptors are internalized. During the course of endocytosis, activated receptors can accumulate within endosomal structures and certain signal-transducing molecules can be recruited to endosomal membranes.
Engedal, Nikolai, Mills, Ian G
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Heredity and Oncogenesis in Childhood
Oncology, 2009The part played by heredity in the genesis of childhood neoplasia was investigated by examining the relative frequency of leukemia and other childhood malignancies in a widely scattered ‘family’ of British descent. It was found that in Canada, England and Wales, and New Zealand, where there are slightly differing incidence rates of malignant disease ...
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