Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy?
Cytokines are small proteins that regulate the growth and functional activity of immune cells, and several have been approved for cancer therapy. Oncolytic viruses are agents that mediate antitumor activity by directly killing tumor cells and inducing ...
Howard L Kaufman +6 more
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Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. [PDF]
Xie J +11 more
europepmc +1 more source
Lynne Braidwood, Kirsty Learmonth, Alex Graham, Joe Conner Virttu Biologics Ltd, Department of Neurology, Southern General Hospital, Glasgow, UK Abstract: Oncolytic herpes simplex virus (HSV1716), lacking the neurovirulence factor ICP34.5, has highly ...
Braidwood L +3 more
doaj
Prophylactic Vaccination and Intratumoral Boost with HER2-Expressing Oncolytic Herpes Simplex Virus Induces Robust and Persistent Immune Response against HER2-Positive Tumor Cells. [PDF]
Delwar Z +10 more
europepmc +1 more source
Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma. [PDF]
Kawamura Y +10 more
europepmc +1 more source
Human Monocytes Are Suitable Carriers for the Delivery of Oncolytic Herpes Simplex Virus Type 1 In Vitro and in a Chicken Embryo Chorioallantoic Membrane Model of Cancer. [PDF]
Reale A +8 more
europepmc +1 more source
Treatment of HPV-Related Uterine Cervical Cancer with a Third-Generation Oncolytic Herpes Simplex Virus in Combination with an Immune Checkpoint Inhibitor. [PDF]
Kagabu M +6 more
europepmc +1 more source
Oncolytic herpes simplex virus (HSV) strains [PDF]
openaire +1 more source
Construction of an IL12 and CXCL11 armed oncolytic herpes simplex virus using the CRISPR/Cas9 system for colon cancer treatment. [PDF]
Zhang N +6 more
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