Results 141 to 150 of about 6,429 (163)
Some of the next articles are maybe not open access.
Oncolytic Herpes Simplex Virus Type 1 and Host Immune Responses
Current Cancer Drug Targets, 2007The use of oncolytic herpes simplex virus type 1 (HSV-1) is a promising strategy for cancer treatment. Accumulating evidence indicates that, aside from the extent of replication capability within the tumor, the efficacy of an oncolytic HSV-1 depends on the extent of induction of host antitumor immune responses.
Hiroshi, Fukuhara, Tomoki, Todo
openaire +2 more sources
Treatment of human breast tumors by oncolytic herpes simplex virus.
Journal of Clinical Oncology, 2010e13605 Background: Oncolytic replication-competent herpes simplex virus (HSV) can infect, replicate and kill tumor cells by a direct cytopathic effect and then spread within the tumor.
R. Liu, J. Wang, J. Li, S. D. Rabkin
openaire +1 more source
Oncolytic Herpes simplex virus - 1 for the treatment of melanoma
2019Oncolytic viruses (OVs) are native or modified viruses that selectively replicate in and lyse tumor cells. The ability of OVs to selectively lyse tumor cells is attributed to disruption of both oncogenic cell signaling pathways and anti-viral machinery in cancer cells.
openaire +1 more source
[The Advances of Oncolytic Herpes Simplex Virus in Cancer Therapy].
Bing du xue bao = Chinese journal of virology, 2018Due to the remarkable ability to target and kill tumor cells, genetically engineering HSV-1 has been widely studied for its potency in cancer treatment. Several oncolytic herpes simplex viruses had been proved to be clinically effective in different phases of clinical trials against multiple cancers, which can also induce good antitumor immunity.
Mengru, Hao +2 more
openaire +1 more source
Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors
2007Oncolytic virus therapy is a promising new strategy for treating cancer that involves replication-competent virus vectors that can replicate in situ in tumor cells, exhibit oncolytic activity by direct cytocidal effects, and then spread throughout the tumor.
Tomoki Todo, Samuel D. Rabkin
openaire +1 more source
A Potent Oncolytic Herpes Simplex Virus for the Therapy of Advanced Prostate Cancer
2004Abstract : Currently there is no cure for prostate cancer once the disease has spread beyond the gland. As a large percentage of patients have advanced disease at the time of diagnosis or after the conventional therapy fails, new treatment strategies are urgently needed.
openaire +1 more source
Engineered Oncolytic Herpes Simplex Virus as Treatment for Glioblastoma
2018Since they were discovered over a century ago, oncolytic viruses have been expected to produce a cure for cancer. Although results so far have not been promising, the FDA approval of an oncolytic virus (T-VEC) for malignant melanoma in the United States in 2015 has yet opened again the door for this therapy as a potential treatment for cancer.
Rúbies Bedós, Marta +1 more
openaire +1 more source
Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo
Molecular Therapy - Oncolytics, 2021Jayeeta Ghose +2 more
exaly