Results 41 to 50 of about 6,429 (163)

Herpes simplex virus 1 as an oncolytic viral therapy for refractory cancers

Frontiers in Oncology, 2022
The need for efficacious and non-toxic cancer therapies is paramount. Oncolytic viruses (OVs) are showing great promise and are introducing new possibilities in cancer treatment with their ability to selectively infect tumor cells and trigger antitumor immune responses. Herpes Simplex Virus 1 (HSV-1) is a commonly selected OV candidate due to its large
Hayle Scanlan, Zachary Coffman, Jeffrey Bettencourt, Timothy Shipley, Debra E. Bramblett   +4 more
openaire   +3 more sources

Oncolytic herpes simplex virus therapy for peripheral nerve tumors

Neurosurgical Focus, 2007
✓Oncolytic viruses are one of many emerging cancer therapies. The surgical management of peripheral nerve tumors carries an inherent risk of damaging the nerves involved and so the search for novel therapies with reduced risk of morbidity continues. In this review the authors discuss the use of oncolytic herpes simplex virus (HSV) in the treatment of ...
Deva S, Jeyaretna, Samuel D, Rabkin, Robert L, Martuza   +2 more
openaire   +2 more sources

Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class

Frontiers in Molecular Biosciences, 2022
Talimogene laherparepvec (T-VEC) is a modified oncolytic herpes Simplex virus, type 1 (HSV-1) encoding granulocyte-macrophage colony stimulating factor (GM-CSF).
Howard L. Kaufman, Howard L. Kaufman, Sophia Z. Shalhout, Gail Iodice   +3 more
doaj   +1 more source

Treatment of breast cancer stem cells with oncolytic herpes simplex virus [PDF]

Cancer Gene Therapy, 2012
Cancer stem cells have recently been isolated from several different solid tumors. In breast cancer, the CD44(+)CD24(-/low) population is considered to comprise stem-like cells. The identification of cancer stem cells has provided new targets for the development of therapeutics.
Li, J, Zeng, W, Huang, Y, Zhang, Q, Hu, P, Rabkin, S D, Liu, R   +6 more
openaire   +4 more sources

Recent advances of oncolytic virus in cancer therapy

Human Vaccines & Immunotherapeutics, 2020
Oncolytic viruses have been taking the front stage in biological therapy for cancer recently. The first and most potent virus to be used in oncolytic virotherapy is human adenovirus.
Moumita Mondal, Jingao Guo, Ping He, Dongming Zhou   +3 more
doaj   +1 more source

Canine Adipose-Derived Mesenchymal Stem Cells (cAdMSCs) as a “Trojan Horse” in Vaccinia Virus Mediated Oncolytic Therapy against Canine Soft Tissue Sarcomas

Viruses, 2020
Several oncolytic viruses (OVs) including various human and canine adenoviruses, canine distemper virus, herpes-simplex virus, reovirus, and members of the poxvirus family, such as vaccinia virus and myxoma virus, have been successfully tested for canine
Ivan Petrov, Ivaylo Gentschev, Anna Vyalkova, Mohamed I. Elashry, Michele C. Klymiuk, Stefan Arnhold, Aladar A. Szalay   +6 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models [PDF]

Gene Therapy, 2016
Cancer stem cells (CSCs), which are a rare population in any type of cancer, including colon cancer, are tumorigenic and responsible for cancer recurrence and metastasis. CSCs have been isolated from a number of different solid tumors recently, although the isolation of CSCs in colon cancer is still challenging.
H, Yang, T, Peng, J, Li, Y, Wang, W, Zhang, P, Zhang, S, Peng, T, Du, Y, Li, Q, Yan, B, Liu   +10 more
openaire   +2 more sources

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Oncolytic herpes simplex virus treatment of metastatic breast cancer

International Journal of Oncology, 2011
The high prevalence and poor prognosis of breast cancer provides a strong rationale for developing new treatment strategies and preventive and therapeutic agents. Oncolytic replication-competent herpes simplex virus (HSV) can infect tumor cells, replicating and killing the cells by direct cytopathic effect and then spreading within the tumor ...
Jiani, Wang, Pan, Hu, Musheng, Zeng, Samuel D, Rabkin, Renbin, Liu   +4 more
openaire   +3 more sources