Results 61 to 70 of about 23,985 (238)
Pharmaceuticals, 2023 The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses.
Nikolas T. Martin +17 more
doaj +1 more source
High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor
Biotechnology and Bioengineering, EarlyView.ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe +5 more
wiley +1 more source
Characterization and comparison of two oncolytic poxvirus variants [PDF]
, 2023 reservedL’utilizzo di virus ingegnerizzati come base per lo sviluppo di vettori oncolitici e vaccini antitumorali rappresenta un approccio promettente al trattamento oncologico.
VERGANI, GILBERTO
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Arming, Pseudotyping, and Enhancing the Efficacy of Oncolytic Measles Virus for a Better Cancer Therapeutic [PDF]
, 2022 Everyone knows someone affected by cancer. It is a heterogeneous malignancy requiring different approaches depending on the source, aggressiveness, and stage of the disease.
Neault, Serge
core +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
The role of autophagy in neoplastic cell response to oncolytic viruses [PDF]
, 2009 Oncolytic conditionally replicating adenoviruses (CRAds) are viral mutants able to selectively replicate in tumour cells. CRAds are considered a promising platform for cancer therapy. dl922-947, bearing a mutation in E1A gene and AdΔΔ, carrying mutations
Botta, Ginevra
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Virus-Protein Corona Replacement Strategy to Improve the Antitumor Efficacy of Intravenously Injected Oncolytic Adenovirus [PDF]
, 2023 Intravenous administration of oncolytic adenoviruses (OVs) is a hopeful tumor therapeutic modality. However, the sharp clearance of OVs by the immune system dampens its effectiveness. Many studies have attempted to extend the circulation of intravenously
Mingyang Liu +23 more
core +1 more source
Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities
Journal for ImmunoTherapy of CancerBackground Heterologous oncolytic virus prime-boost vaccination is emerging as a promising cancer immunotherapy to establish potent antitumor immunity.
Marie-Claude Bourgeois-Daigneault +8 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2018 Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon pathway, a protein-signaling cascade that alerts the immune system and limits virus propagation ...
Donald Bastin +8 more
doaj +1 more source
Detecting communities when order and direction matter in social network analysis
Canadian Journal of Statistics, EarlyView.Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley +1 more source