Results 41 to 50 of about 19,047 (182)

Oncolytic potency and reduced virus tumor-specificity in oncolytic virotherapy. A mathematical modelling approach. [PDF]

PLoS ONE, 2017
In the present paper, we address by means of mathematical modeling the following main question: How can oncolytic virus infection of some normal cells in the vicinity of tumor cells enhance oncolytic virotherapy?
Khaphetsi Joseph Mahasa, Amina Eladdadi, Lisette de Pillis, Rachid Ouifki   +3 more
doaj   +1 more source

Oncolytic Virus

, 2023
Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells ...
openaire   +2 more sources

Oncolytic myxoma virus: The path to clinic [PDF]

Vaccine, 2013
Many common neoplasms are still noncurative with current standards of cancer therapy. More therapeutic modalities need to be developed to significantly prolong the lives of patients and eventually cure a wider spectrum of cancers. Oncolytic virotherapy is one of the promising new additions to clinical cancer therapeutics.
Winnie M, Chan, Masmudur M, Rahman, Grant, McFadden   +2 more
openaire   +3 more sources

Oncolytic virus therapy for cancer

Oncolytic Virotherapy, 2013
The use of oncolytic viruses to treat cancer is based on the selection of tropic tumor viruses or the generation of replication selective vectors that can either directly kill infected tumor cells or increase their susceptibility to cell death and apoptosis through additional exposure to radiation or chemotherapy.
Joe, Goldufsky, Shanthi, Sivendran, Sara, Harcharik, Michael, Pan, Sebastian, Bernardo, Richard H, Stern, Philip, Friedlander, Carl E, Ruby, Yvonne, Saenger, Howard L, Kaufman   +9 more
openaire   +3 more sources

Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients

Journal of Translational Medicine, 2012
Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed.
Patil Sandeep S, Gentschev Ivaylo, Nolte Ingo, Ogilvie Gregory, Szalay Aladar A   +4 more
doaj   +1 more source

Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis

Scientific Reports, 2021
Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem ...
Amanda W. K. AuYeung, Robert C. Mould, Ashley A. Stegelmeier, Jacob P. van Vloten, Khalil Karimi, J. Paul Woods, James J. Petrik, Geoffrey A. Wood, Byram W. Bridle   +8 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Study of Oncolytic Virus Preservation and Formulation

Pharmaceuticals, 2023
In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying tumor angiogenesis and triggering a broad bystander effect.
Lina Pan, Xiyu Liu, Dianfa Fan, Zhangbo Qian, Xinjun Sun, Pan Wu, Liping Zhong   +6 more
openaire   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Advances in cell-based delivery of oncolytic viruses as therapy for lung cancer

Molecular Therapy: Oncology
Lung cancer’s intractability is enhanced by its frequent resistance to (chemo)therapy and often high relapse rates that make it the leading cause of cancer death worldwide.
Giti Esmail Nia, Elahe Nikpayam, Molood Farrokhi, Azam Bolhassani, Ralph Meuwissen   +4 more
doaj   +1 more source