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The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
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Application progress of oncolytic virus combined with immunotherapy in the treatment of malignant tumors [PDF]
Zhongguo aizheng zazhiThe oncolytic virus (OV) therapy utilizes natural or genetically modified viruses to specifically target and infect tumor cells, leading to the destruction of cancer cells by the replication of the virus itself.
LIANG Yingyun, CHEN Jianhua
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, 2023 Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells ...
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Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer
, 2013 Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C +3 more
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Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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Journal of Translational Medicine, 2012 Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed.
Patil Sandeep S +4 more
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Scientific Reports, 2021 Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem ...
Amanda W. K. AuYeung +8 more
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Lung cancer and oncolytic virotherapy——enemy's enemy
Translational Oncology, 2023 Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li +3 more
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ODE models for oncolytic virus dynamics [PDF]
Journal of Theoretical Biology, 2010 Replicating oncolytic viruses are able to infect and lyse cancer cells and spread through the tumor, while leaving normal cells largely unharmed. This makes them potentially useful in cancer therapy, and a variety of viruses have shown promising results in clinical trials.
Komarova, Natalia L., Wodarz, Dominik
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Oncolytic virus therapy for cancer
Oncolytic Virotherapy, 2013 The use of oncolytic viruses to treat cancer is based on the selection of tropic tumor viruses or the generation of replication selective vectors that can either directly kill infected tumor cells or increase their susceptibility to cell death and apoptosis through additional exposure to radiation or chemotherapy.
Joe, Goldufsky +9 more
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