Results 21 to 30 of about 19,047 (182)
Oncolytic H-1 Parvovirus Enters Cancer Cells through Clathrin-Mediated Endocytosis
Viruses, 2020 H-1 protoparvovirus (H-1PV) is a self-propagating virus that is non-pathogenic in humans and has oncolytic and oncosuppressive activities. H-1PV is the first member of the Parvoviridae family to undergo clinical testing as an anticancer agent.
Tiago Ferreira +5 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2021 The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala +3 more
doaj +1 more source
Recent advances in oncolytic virus therapy for hepatocellular carcinoma
Frontiers in Oncology, 2023 Hepatocellular carcinoma (HCC) is a highly refractory cancer and the fourth leading cause of cancer-related mortality worldwide. Despite the development of a detailed treatment strategy for HCC, the survival rate remains unsatisfactory.
Licheng Zhu +14 more
doaj +1 more source
Neutrophils in oncolytic virus immunotherapy. [PDF]
Front ImmunolOncolytic viruses have emerged as a highly promising modality for cancer treatment due to their ability to replicate specifically within tumors, carry therapeutic genes, and modulate the immunosuppressive tumor microenvironment through various mechanisms. Additionally, they show potential synergy with immune checkpoint inhibitors.
Zhou D, Zhang C, Sun J, Yuan M.
europepmc +4 more sources
Suppression of CCDC6 sensitizes tumor to oncolytic virus M1
Neoplasia: An International Journal for Oncology Research, 2021 Oncolytic virus is an effective therapeutic strategy for cancer treatment, which exploits natural or manipulated viruses to selectively target and kill cancer cells.
Ying Liu +12 more
doaj +1 more source
Oncolytic Viruses: Immunotherapy Drugs for Gastrointestinal Malignant Tumors
Frontiers in Cellular and Infection Microbiology, 2022 Oncolytic virus therapy has advanced rapidly in recent years. Natural or transgenic viruses can target tumor cells and inhibit tumor growth and metastasis in various ways without interfering with normal cell and tissue function.
Qingbo Li +9 more
doaj +1 more source
H-1 Parvovirus as a Cancer-Killing Agent: Past, Present, and Future
Viruses, 2019 The rat protoparvovirus H-1PV is nonpathogenic in humans, replicates preferentially in cancer cells, and has natural oncolytic and oncosuppressive activities. The virus is able to kill cancer cells by activating several cell death pathways.
Clemens Bretscher, Antonio Marchini
doaj +1 more source
Tumor Restrictions to Oncolytic Virus [PDF]
Biomedicines, 2014 Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models. One reason is premature oncolytic virus clearance in humans, which is a reasonable assumption considering the immune-stimulating nature of the oncolytic agents.
Markus Vähä-Koskela, Ari Hinkkanen
openaire +3 more sources
Frontiers in Immunology, 2019 Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune responses creating a “cold” immunosuppressive tumor microenvironment. Oncolytic virotherapy is emerging as a promising approach to revert tumor immunosuppression and enhance
Antonio Marchini +6 more
doaj +1 more source
Oncolytic Virotherapy for Cancer: Clinical Experience
Biomedicines, 2021 Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
Shyambabu Chaurasiya +2 more
doaj +1 more source