Results 21 to 30 of about 23,985 (238)

Oncolytic Virotherapy for Cancer: Clinical Experience

Biomedicines, 2021
Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
Shyambabu Chaurasiya, Yuman Fong, Susanne G. Warner   +2 more
doaj   +1 more source

Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity [PDF]

, 2022
Summary: The emergence of cellular resistances to oncolytic viruses is an underexplored process that could compromise the efficacy of cancer virotherapy. Here, we isolated and characterized B16 mouse melanoma cells that evolved resistance to an oncolytic
Rafael Sanjuán, Larrieux, Alejandra, Alejandra Larrieux, Sanjuán, Rafael   +3 more
core   +1 more source

Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy

Molecular Therapy: Oncolytics, 2022
Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize with
Boaz Wong, Anabel Bergeron, Nouf Alluqmani, Glib Maznyi, Andrew Chen, Rozanne Arulanandam, Jean-Simon Diallo   +6 more
doaj   +1 more source

Oncolytic Virus Animal Model [PDF]

, 2023
 To fully optimize oncolytic virotherapy and provide meaningful mechanistic insight, it is critical to have animal models for oncolytic virus study in various tumor types. 
candy swift (14858320)
core   +1 more source

Application progress of oncolytic virus combined with immunotherapy in the treatment of malignant tumors [PDF]

Zhongguo aizheng zazhi
The oncolytic virus (OV) therapy utilizes natural or genetically modified viruses to specifically target and infect tumor cells, leading to the destruction of cancer cells by the replication of the virus itself.
LIANG Yingyun, CHEN Jianhua
doaj   +3 more sources

Adenovirus as a Vector and Oncolytic Virus

Current Issues in Molecular Biology, 2023
Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as an oncolytic virus have recently drawn attention. Thus,
Wataru Matsunaga, Akinobu Gotoh
openaire   +3 more sources

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Enrico N. De Toni, Jennifer Altomonte, Roland M Schmid, Schneider, Günter, Schmid, Roland M., Rizzani Antonia, Thasler Wolfgang E., Ebert Oliver, Thasler, Wolfgang E., Schmid Roland M., Marozin, Sabrina, De Toni, Enrico N., Kato, Nobuyuki, Marozin Sabrina, Wolfgang E Thasler, Wolfgang E. Thasler, Enrico N De Toni, Altomonte, Jennifer, Alexandra Junger, De Toni Enrico N., Altomonte Jennifer, Ebert, Oliver, Günter Schneider, Oliver Ebert, Sabrina Marozin, Junger Alexandra, Kato Nobuyuki, Roland M. Schmid, Junger, Alexandra, Schneider Günter, Nobuyuki Kato, Rizzani, Antonia, Antonia Rizzani   +32 more
core   +1 more source

Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Hepatocellular Carcinoma Cells

Marine Drugs, 2022
Oncolytic vaccinia virus has been developed as a novel cancer therapeutic drug in recent years. Our previous studies demonstrated that the antitumor effect of oncolytic vaccina virus harboring Aphrocallistes vastus lectin (oncoVV-AVL) was significantly ...
Riqing Jiang, Yufeng Qiu, Xiaomei Zhang, Ningning Zhou, Xiaoyuan Jia, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
doaj   +1 more source

Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving Oncolytic Function

Molecular Therapy: Oncolytics, 2019
Vaccinia virus (VV) has been utilized in oncolytic virotherapy, but it risks a host antiviral immune response. VV has an extracellular enveloped virus (EEV) form consisting of a normal virion covered with a host-derived outer membrane that enables its ...
Motomu Nakatake, Hajime Kurosaki, Nozomi Kuwano, Kosuke Horita, Mai Ito, Hiromichi Kono, Tomotaka Okamura, Kosei Hasegawa, Yasuhiro Yasutomi, Takafumi Nakamura   +9 more
doaj   +1 more source

Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells

Viruses, 2020
We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Ivan Trus, Nathalie Berube, Peng Jiang, Janusz Rak, Volker Gerdts, Uladzimir Karniychuk   +5 more
doaj   +1 more source