Results 11 to 20 of about 1,058,979 (232)
Oncolytic Virotherapy with Myxoma Virus [PDF]
Journal of Clinical Medicine, 2020 Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers. They selectively infect and kill cancer cells while sparing the normal counterparts, expose cancer- specific antigens and activate the host immune system against both viral and tumor determinants.
Diana Thomas +2 more
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Measles Virus as an Oncolytic Immunotherapy [PDF]
Cancers, 2021 Measles virus (MeV) preferentially replicates in malignant cells, leading to tumor lysis and priming of antitumor immunity. Live attenuated MeV vaccine strains are therefore under investigation as cancer therapeutics. The versatile MeV reverse genetics systems allows for engineering of advanced targeted, armed, and shielded oncolytic viral vectors ...
Christine E Engeland, Guy Ungerechts
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Adenovirus as a Vector and Oncolytic Virus
Current Issues in Molecular Biology, 2023 Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as an oncolytic virus have recently drawn attention. Thus,
Akinobu Gotoh, Wataru Matsunaga
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Recent progress in combination therapy of oncolytic vaccinia virus
Frontiers in ImmunologyIn recent years, oncolytic viruses have emerged as promising agents for treating various cancers. An oncolytic virus is a non-pathogenic virus that, due to genetic manipulation, tends to replicate in and cause lysis of cancerous cells while leaving ...
Seyedeh Nasim Mirbahari +12 more
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Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in the treatment of malignant tumors [PDF]
Zhongguo aizheng zazhi, 2023 Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future.
Expert Committee on Immunotherapy of Chinese Society of Clinical Oncology , Professional Committee on Cancer Biotherapy of Shanghai Anticancer Association
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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma [PDF]
Cell Reports MedicineSummary: Long-term survival of glioblastoma multiforme (GBM) remains challenging, spurring the development of novel therapies such as oncolytic virus therapy.
Chen Guo +18 more
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Oncolytic Virus Immunotherapy [PDF]
Cancers, 2021 Oncolytic viruses (OVs) were originally developed as direct cytotoxic agents but have been increasingly recognised as a form of immunotherapy [...]
Marchini, Antonio +2 more
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Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
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Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
Nature Communications, 2021 Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell
Amit Kulkarni +18 more
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Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells
Viruses, 2022 Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the H-1PV life cycle may provide the
Tiago Ferreira +9 more
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