Results 11 to 20 of about 33,145 (233)
Oncolytic Virus Immunotherapy [PDF]
Cancers, 2021 Oncolytic viruses (OVs) were originally developed as direct cytotoxic agents but have been increasingly recognised as a form of immunotherapy [...]
Marchini, Antonio +2 more
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Oncolytic Virotherapy with Myxoma Virus [PDF]
Journal of Clinical Medicine, 2020 Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers. They selectively infect and kill cancer cells while sparing the normal counterparts, expose cancer- specific antigens and activate the host immune system against both viral and tumor determinants.
Masmudur M. Rahman, Grant McFadden
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Suppression of CCDC6 sensitizes tumor to oncolytic virus M1
Neoplasia: An International Journal for Oncology Research, 2021 Oncolytic virus is an effective therapeutic strategy for cancer treatment, which exploits natural or manipulated viruses to selectively target and kill cancer cells.
Ying Liu +12 more
doaj +1 more source
Oncolytic Viruses: Immunotherapy Drugs for Gastrointestinal Malignant Tumors
Frontiers in Cellular and Infection Microbiology, 2022 Oncolytic virus therapy has advanced rapidly in recent years. Natural or transgenic viruses can target tumor cells and inhibit tumor growth and metastasis in various ways without interfering with normal cell and tissue function.
Qingbo Li +9 more
doaj +1 more source
Measles Virus as an Oncolytic Immunotherapy [PDF]
Cancers, 2021 Measles virus (MeV) preferentially replicates in malignant cells, leading to tumor lysis and priming of antitumor immunity. Live attenuated MeV vaccine strains are therefore under investigation as cancer therapeutics. The versatile MeV reverse genetics systems allows for engineering of advanced targeted, armed, and shielded oncolytic viral vectors ...
Christine E. Engeland, Guy Ungerechts
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Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs [PDF]
, 2013 Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by ...
Braidwood, L. +3 more
core +1 more source
Oncolytic Virotherapy for Cancer: Clinical Experience
Biomedicines, 2021 Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
Shyambabu Chaurasiya +2 more
doaj +1 more source
Neutrophils in oncolytic virus immunotherapy. [PDF]
Front ImmunolOncolytic viruses have emerged as a highly promising modality for cancer treatment due to their ability to replicate specifically within tumors, carry therapeutic genes, and modulate the immunosuppressive tumor microenvironment through various mechanisms. Additionally, they show potential synergy with immune checkpoint inhibitors.
Zhou D, Zhang C, Sun J, Yuan M.
europepmc +4 more sources
H-1 Parvovirus as a Cancer-Killing Agent: Past, Present, and Future
Viruses, 2019 The rat protoparvovirus H-1PV is nonpathogenic in humans, replicates preferentially in cancer cells, and has natural oncolytic and oncosuppressive activities. The virus is able to kill cancer cells by activating several cell death pathways.
Clemens Bretscher, Antonio Marchini
doaj +1 more source
Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy
Molecular Therapy: Oncolytics, 2022 Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize with
Boaz Wong +6 more
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