Results 31 to 40 of about 19,047 (182)
Oncolytic virus therapy in hepatocellular carcinoma. [PDF]
Oncol ResLiver cancer is the fifth most common cancer in the world, with China bearing a disproportionate burden of cases. Typically diagnosed at advanced stages, liver cancer often utilizes surgical treatments such as resection, transcatheter hepatic artery chemoembolization (TACE), and radiofrequency ablation.
Ye Y, Liu Y.
europepmc +3 more sources
Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy
Molecular Therapy: Oncolytics, 2022 Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize with
Boaz Wong +6 more
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Application progress of oncolytic virus combined with immunotherapy in the treatment of malignant tumors [PDF]
Zhongguo aizheng zazhiThe oncolytic virus (OV) therapy utilizes natural or genetically modified viruses to specifically target and infect tumor cells, leading to the destruction of cancer cells by the replication of the virus itself.
LIANG Yingyun, CHEN Jianhua
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Marine Drugs, 2022 Oncolytic vaccinia virus has been developed as a novel cancer therapeutic drug in recent years. Our previous studies demonstrated that the antitumor effect of oncolytic vaccina virus harboring Aphrocallistes vastus lectin (oncoVV-AVL) was significantly ...
Riqing Jiang +8 more
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Oncolytic Virus-Induced Autophagy in Glioblastoma [PDF]
Cancers, 2021 Autophagy is a catabolic process that allows cells to scavenge damaged organelles and produces energy to maintain cellular homeostasis. It is also an effective defense method for cells, which allows them to identify an internalized pathogen and destroy it through the fusion of the autophagosome and lysosomes.
Margarita Kamynina +5 more
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Viruses, 2020 We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Ivan Trus +5 more
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Molecular Therapy: Oncolytics, 2019 Vaccinia virus (VV) has been utilized in oncolytic virotherapy, but it risks a host antiviral immune response. VV has an extracellular enveloped virus (EEV) form consisting of a normal virion covered with a host-derived outer membrane that enables its ...
Motomu Nakatake +9 more
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Molecular Therapy: Oncolytics, 2019 The efficacy of immune checkpoint blockade therapy against immunologically “cold” tumors can be enhanced by applying the checkpoint inhibitors in combination with oncolytic viruses.
Yujie Zhu +9 more
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Development and application of oncolytic viruses as the nemesis of tumor cells
Frontiers in Microbiology, 2023 Viruses and tumors are two pathologies that negatively impact human health, but what occurs when a virus encounters a tumor? A global consensus among cancer patients suggests that surgical resection, chemotherapy, radiotherapy, and other methods are the ...
Xiao Zhu +8 more
doaj +1 more source
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
Journal for ImmunoTherapy of Cancer, 2023 Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection ...
Huy-Dung Hoang +15 more
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