Results 221 to 230 of about 31,178 (269)
Some of the next articles are maybe not open access.
Oncolytic viruses: adenoviruses
Virus Genes, 2017Tumor-selectively replicating (oncolytic) viruses are promising tools for therapy of solid cancers and have been initially developed to achieve potent tumor lysis with acceptable side effects on healthy tissue. However, in recent years, oncolytic viruses have been recognized as therapeutic vehicles exhibiting multipronged anti-tumoral activity.
Julia Niemann, Florian Kühnel
openaire +2 more sources
Oncolytic Viruses and Cancer Immunotherapy
Current Oncology Reports, 2022Oncolytic viruses (OVs) exert their antitumor effect through selective killing of cancer cells and induction of host anti-tumor immunity. This review aims to summarize the recent and current trials with OVs for the treatment of lung cancer.Several OVs have been developed for the treatment of lung cancer including adenovirus, coxsackievirus B3, reovirus,
Jyoti, Malhotra, Edward S, Kim
openaire +2 more sources
Infectious Diseases in Clinical Practice, 2009
Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
openaire +1 more source
Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
openaire +1 more source
Investigational New Drugs, 1999
Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored.
openaire +2 more sources
Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored.
openaire +2 more sources
Evolution of oncolytic viruses
Current Opinion in Virology, 2015Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies.
Rafael Sanjuán, Valery Z Grdzelishvili
openaire +2 more sources
MicroRNAs and oncolytic viruses
Current Opinion in Virology, 2015MicroRNAs regulate gene expression in mammalian cells and often exhibit tissue-specific expression patterns. Incorporation of microRNA target sequences can be used to control exogenous gene expression and viral tropism in specific tissues to enhance the therapeutic indices of oncolytic viruses expressing therapeutic transgenes. Continued development of
Autumn J, Ruiz, Stephen J, Russell
openaire +2 more sources
Oncolytic viruses and immunity
Current Opinion in Immunology, 2018Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe of OVs.
Shyambabu, Chaurasiya +2 more
openaire +2 more sources
Future Directions: Oncolytic Viruses
Clinical Lung Cancer, 2004Oncolytic viruses offer a promising new modality for cancer treatment. The strategy of this therapy is to develop viruses capable of selectively infecting and replicating in malignant tumor cells. Oncolytic viruses can spread and destroy malignant tumors without deleterious effects in normal tissues.
Liang, You +4 more
openaire +2 more sources
Oncolytic viruses in radiation oncology
Radiotherapy and Oncology, 2011Oncolytic viruses are investigational cancer treatments. They are currently being assessed as single agents or in combination with standard therapies such as external beam radiotherapy - a DNA damaging agent that is a standard of care for many tumour types.
Yann, Touchefeu +2 more
openaire +2 more sources
MicroRNAs fine-tune oncolytic viruses
Nature Biotechnology, 2008Targeting by tissue-specific microRNAs enhances the efficacy and safety of tumor-killing viruses.
John C, Bell, David, Kirn
openaire +2 more sources