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Advances in Gene Therapy with Oncolytic Viruses and CAR-T Cells and Therapy-Related Groups. [PDF]
Curr Issues Mol BiolMatsuzaka Y, Yashiro R.
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Development of oncolytic viruses for cancer therapy. [PDF]
Translational research : the journal of laboratory and clinical medicine, 2021 Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses (OVs) to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune ...
Noraini Abd-Aziz, C. Poh
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Integrating oncolytic viruses in combination cancer immunotherapy
Nature Reviews Immunology, 2018Praveen Bommareddy +2 more
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Nano Based-Oncolytic viruses for Cancer therapy.
Critical reviews in oncology/hematology, 2023Oncolytic viruses (OV) are an attractive prospect due to their dual attack mechanism of direct cell lysis and potentiation of an antitumor immune response.
Mobarakeh Ajam-Hosseini +2 more
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Nature Reviews Cancer, 2002
Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses.
Lynda K. Hawkins, David Kirn
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Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses.
Lynda K. Hawkins, David Kirn
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Developing oncolytic viruses for clinical use: A consortium approach [PDF]
Cytokine and Growth Factor Reviews, 2020 The use of oncolytic viruses forms an appealing approach for cancer treatment. On the one hand the viruses replicate in, and kill, tumor cells, leading to their intra-tumoral amplification.
Martine Lamfers +2 more
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Oncolytic viruses: adenoviruses
Virus Genes, 2017Tumor-selectively replicating (oncolytic) viruses are promising tools for therapy of solid cancers and have been initially developed to achieve potent tumor lysis with acceptable side effects on healthy tissue. However, in recent years, oncolytic viruses have been recognized as therapeutic vehicles exhibiting multipronged anti-tumoral activity.
Julia Niemann, Florian Kühnel
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MicroRNAs and oncolytic viruses
Current Opinion in Virology, 2015MicroRNAs regulate gene expression in mammalian cells and often exhibit tissue-specific expression patterns. Incorporation of microRNA target sequences can be used to control exogenous gene expression and viral tropism in specific tissues to enhance the therapeutic indices of oncolytic viruses expressing therapeutic transgenes. Continued development of
Autumn J, Ruiz, Stephen J, Russell
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Oncolytic viruses and immunity
Current Opinion in Immunology, 2018Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe of OVs.
Shyambabu, Chaurasiya +2 more
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